BackgroundIt has been confirmed that the connective tissue growth factor (CTGF) gene rs9402373 polymorphism is associated with fibrotic and inflammatory diseases. However, studies on relationship between polymorphisms in CTGF bowel disease (IBD) remain rare. Therefore, aim of this study was to assess association IBD susceptibility a Chinese population.Materials methodsTo establish an amplificat...

Thesis Abstract Several cytokines are known to be involved in the pathogenesis of non-Hodgkin Lymphomas (NHL). Given importance understanding genetic predisposition NHL, this work was designed study impact IL-10 (-1082 G/A; rs1800896 and -819 C/T; rs1800871), IL-6 (-174 G/C; rs1800795) CD38 (184C/G; rs6449182) gene polymorphisms on susceptibility Egyptians NHL. Both loci IL10 were genotyped usi...

lactoferrin is a glycoprotein with molecular weight 80 kda iron-binding bond, which is composed of 690 amino acids. in most mammalian body fluids such as sweat, semen, tears, and saliva and milk neutrophil granules there. bovine lactoferrin gene be associated with susceptibility/resistance to mastitis and even with some economically important production traits. this study was carried out to det...

apolipoprotein e (apo e) is a structural constituent of several serum lipoprotein classes. it plays an important role in lipid metabolism by acting as a ligand for low-density lipoprotein (ldl) and chylomicron remnant receptors. three common alleles called e2, e3 and e4 have been described, which code for three protein isoforms (e2, e3 and e4). the polymorphism is clinically significant, and it...

objective: to investigate the association of c631t single nucleotide polymorphisms in spo11 gene with male infertilityfollowed by an in silico approach. spo11 is a gene involved in meiosis and spermatogenesis process, which in humans, this gene is located on chromosome 20 (20q13.2-13.3) with 13 exons. materials and methods: in a case-control study, 200 blood samples were collected from the ivf ...

objective(s): foxp3 gene is an x-linked gene that encodes foxp3 protein, an essential transcription factor in cd4+cd25+foxp3+ regulatory t (treg) cells.  we aimed, in the present study, to investigate the association of two foxp3 polymorphisms, -2383 c/t (rs3761549) and ivs9+459 t/c (rs2280883), with lung cancer. materials and methods:  in a case-control study we analyzed genotypes and alleles ...

how to cite this article: mozafari h, taghikhani m, khatami sh, alaei mr, vaisi-raygani a, rahimi z. chitotriosidase activity and gene polymorphism in iranian patients with gaucher disease and sibling carriers. iran j child neurol. autumn 2016; 10(4):62-70. abstract objective chitotriosidase (ct) activity is a useful biomarker for diagnosis and monitoring of gaucher disease (gd). its applicatio...

an attempt has been made to analyze the distribution of the beta-lactoglobulin genotype in swamp buffaloes and murrah buffaloes utilizing polymerase chain reaction-restriction fragment length polymorphism(pcr-rflp). blood samples were taken from 50 swamp buffaloes and 50 murrah buffaloes. the dna was extracted by the phenol-chloroform method. the pcr-rflp was performed using beta-lactoglobulin ...