There are various types of benign hepatocellular nodular lesions, and their diagnostic criteria were formulated in detail. However, in 2010, the new World Health Organization (WHO) classification introduced immunohistochemical diagnostic criteria for hepatocellular adenoma (HCA) reflecting molecular pathological properties, and HCA was classified into 4 subtypes. These criteria were useful for ...

In a 49 year old male, a chronic alcoholic with hepatomegaly, a subcapsular nodular lesion was detected in the right lobe of the liver. On fine needle aspiration cytology, hepatocellular carcinoma was considered. Excision of the lesion showed features of nonclassical focal nodular hyperplasia with large cell dysplasia that caused the diagnostic dilemma on cytology.

Hepatic lesions are frequently identified incidentally on • imaging performed for other purposes. With the exception of large lesions, benign hepatic neo• plasms are typically asymptomatic. With current high quality imaging, it is possible to differentiate • the majority of hepatic neoplasms as benign or malignant. Resection of indeterminant, worrisome lesions is generally • preferred over biop...