In 1994, the term "Pick complex" was proposed to indicate significant clinical and pathological overlapping between primary progressive aphasia, frontal lobe dementia and corticobasal degeneration. We report the case of a 60-year-old man, who initially presented progressive non-fluent aphasia with orofacial apraxia, and subsequently, over a period of 3 years, developed mutism, pathological laug...

The purpose of this study is to document prosodic interactivity, and its preservation in a woman with non-fluent aphasia. Fundamental frequency and sound pressure level records are examined for sinusoidal models. In-phase and antiphase partner relationships in these models may represent synchrony. These measurements demonstrate that prosodic management of conversational rhythms is robust even w...

This critical review examines the effectiveness of script training intervention with individuals with chronic, non-fluent aphasia with respect to improved rate of speech and percentage of script-related content words used. Study designs include: delayed treatment, multiple baseline, single subject study designs and a qualitative study. Overall, the results indicate that script training interven...

The effect of typicality of category exemplars on naming performance was investigated using a single subject experimental design across participants and behaviors in four patients with fluent aphasia. Participants received a semantic feature treatment to improve naming of either typical or atypical examples, while generalization was tested on the untrained examples of the category. The order of...

The role of the right hemisphere for language processing and successful therapeutic interventions in aphasic patients is a matter of debate. This study explored brain activation in right-hemispheric areas and left-hemispheric perilesional areas in response to language tasks in chronic non-fluent aphasic patients before and after constraint-induced aphasia therapy (CIAT). In particular, we analy...

We report the naming performance of a fluent aphasic, DP, who shows a striking dissociation between semantic and phonological (nonword) errors: he produced numerous semantic errors but virtually no phonological errors. DP's pattern of performance is the reverse of that reported for patient DM (Caramazza, Papagno, & Ruml, 2000), who only made phonological errors in a naming task. These patterns ...

Postictal aphasia has been described in left temporal lobe seizures. It may be of fluent, non-fluent or global type. We present here a patient who displayed signs of mixed transcortical aphasia (MTCA). The patient was a 67 year old man who underwent excision of a left frontal parasagittal meningioma in 1987. Since then he has been treated with phenytoin for generalized tonic-clonic seizures (GT...

Primary progressive aphasia (PPA) is a clinical syndrome diagnosed when three core criteria are met. First, there should be a language impairment (i.e., aphasia) that interferes with the usage or comprehension of words. Second, the neurological work-up should determine that the disease is neurodegenerative, and therefore progressive. Third, the aphasia should arise in relative isolation, withou...

Objective: To investigate, and establish the neural correlates of, syntactic deficits in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)-ALS, as compared to primary non-fluent aphasia (PNFA) and controls. Method: Syntactic deficits were evaluated using a reduced version of the Test for Reception of Grammar (TROG) and voxel-based morphometry (VBM) analysis was conducted.

Previous surveys of stroke populations have offered only cursory information on language disturbance, and, conversely, few surveys of aphasic populations have dealth exclusively with stroke or with acute phenomena. This paper describes aphasia in 850 acute stroke patients consecutively registered by the Harlem Regional Stroke Program, of whom 177 (21%) were aphasic; of these, nine were of Broca...