Cerebral blood flow mapping with stable xenon-enhanced computed tomography (Xe/CT) was performed in conjunction with conventional computed tomography (CT) within the first 8 hours after the onset of symptoms in seven patients with cerebral infarction. Six patients had hemispheric infarctions, and one had a progressive brainstem infarction. Three patients with very low (less than 10 ml/100 g/min...

For a pair of elastically mounted circular cylinders in tandem configuration, the downstream cylinder may experience wake-induced vibration (WIV) due to hydrodynamic excitation associated with wake behind upstream cylinder. In addition WIV, also be simultaneously subject vortex-induced (VIV) vortex shedding its own wake. This nonlinear coupled wake-vortex interaction can result sustained large-...

BACKGROUND This study investigated the effects of amlodipine, an L-type calcium channel blocker, on stroke size after focal brain ischemia in apolipoprotein E-deficient (ApoE KO) mice. METHODS Mice were subjected to middle cerebral artery (MCA) occlusion after being given a high-cholesterol (HCD) or normal diet for 10 weeks with or without amlodipine at a nonhypotensive dose of 3 mg/kg/day. I...

BACKGROUND The role of angiotensin II receptor subtypes was investigated in focal brain ischemia induced by middle cerebral artery (MCA) occlusion. METHODS AND RESULTS In Agtr2+ (wild-type) mice, MCA occlusion induced focal ischemia of approximately 20% to 30% of the total area in coronal section of the brain. The ischemic area was significantly larger in angiotensin II type 2 receptor-defici...

OBJECTIVE The basal activity of p38 MAPK has recently been shown to impair myocardial contractility. This kinase is activated by ischemia and short-term hibernation. We hypothesized that p38 MAPK activation may contribute to the contractile deficit that characterizes low-flow ischemia. METHODS In Langendorff-perfused isolated C57BL/6 mouse hearts, perfusion pressure was reduced from 85 to 15 ...

Hypofrontality in schizophrenia has been a frequent but not consistent finding in regional cerebral blood flow studies. However, the contributions of subject and state variables such as age, education, task activation, and anxiety, some of which are known to influence blood flow profiles, have not been thoroughly examined in this population. Here, in a sample including 24 normal, 18 schizophren...

A numerical study of atmospheric turbulence effects on wind-turbine wakes is presented. Large-eddy simulations of neutrally-stratified atmospheric boundary layer flows through stand-alone wind turbines were performed over homogeneous flat surfaces with four different aerodynamic roughness lengths. Emphasis is placed on the structure and characteristics of turbine wakes in the cases where the in...

A combination of medial temporal lobe atrophy, shown by computed tomography, and reduced blood flow in the parietotemporal cortex, shown by single photon emission tomography, was found in 86% (44/51) of patients with a clinical diagnosis of senile dementia of the Alzheimer type (SDAT). The same combination of changes was found in four out of 10 patients with other clinical types of dementia and...

PURPOSE Few studies have been conducted to investigate the effects, if any, of specific medication used to manage the symptoms of attention deficit/hyperactivity disorder (ADHD) as a risk factor for dental caries. A reported side-effect of the medication is a reduction in saliva. Healthy saliva has been shown to play many important functions in the prevention of dental caries. The focus of this...

BACKGROUND Spinal radiculomedullary artery aneurysms are extremely rare. Treatment should be tailored to clinical presentation, distal aneurysm flow, and lesion anatomical features. When a surgical occlusion is planned, it is necessary to evaluate whether intraoperative monitoring (IOM) should be considered as an indispensable tool to prevent potential spinal cord ischemia. METHODS We present...