PURPOSE To compare the pharmacologic properties of tamsulosin and alfuzosin in isolated prostatic and iris dilator smooth muscle from pigmented rabbits. SETTING UROsphere Laboratories, Université Paul Sabatier, Toulouse, France. METHODS Prostatic and iris dilator smooth muscle strips were placed in organ baths. A concentration-response curve to phenylephrine was compared before and after in...

Previous studies demonstrate how the intraoperative floppy iris syndrome (IFIS) is associated with different risk factors, including systemic diseases and alpha-1 antagonist drugs, the main one being tamsulosin which alleviates benign prostate hypertrophia symptoms.1 This drug is very efficient for urologists as it delays or avoids prostate surgery although it complicates in an extraordinary ma...

BACKGROUND To determine occurrence of features of intraoperative floppy iris syndrome (IFIS) during cataract surgery in patients taking systemic alpha-antagonists (AA). METHODS We prospectively studied patients on AA and who underwent phacoemulsification. The following were recorded: pupil diameter preoperatively, iris flaccidity, iris prolapse and peroperative miosis. RESULTS We studied 40...

Intraoperative "floppy-iris" syndrome is a novel entity that was initially described in 2005 by Chang and Campbell who encountered it during cataract surgery. The manifestations include a triad of the following intraoperative findings: (a) flaccid iris stroma leading to fluttering and bellowing of the iris, (b) prolapse of the iris through the surgical incisions, and (c) progressive pupil const...

A NEW pupil expansion ring can greatly facilitate phacoemulsification in eyes with small pupils, including those with weak zonules, according to the device’s developer, Boris Malyugin MD PhD, S Fyodorov Eye Microsurgery Complex, Moscow, Russia. The pupillary ring uses the scroll principle to capture and expand the iris margin.The device is composed of 5-0 polypropylene and is square in shape. I...

According to an online survey, most members of the American Society of Cataract and Refractive Surgery believe that tamsulosin makes cataract surgery more difficult (95%) and increases the risks of surgery (77%). Commonly reported complications of intraoperative floppy-iris syndrome (IFIS) were significant iris trauma and posterior capsule rupture, with 52% and 23% of respondents, respectively,...

The prevalence of benign prostate hyperplasia (BPH) and cataract increases with age. Both diseases may develop concomitantly and may affect almost 50% of elderly men as comorbidities. Cataract is treated surgically and it has been reported that there may be an association between use of alpha-blockers for BPH, particularly alpha1A-adrenergic receptor selective drugs, and complications of catara...