Resorcinol based bis-chalcones (2a-d) and flavones (3a-d) were synthesized and evaluated for their antimicrobial activity. Bis-chalcones (2a-d) were prepared by condensing 1,1 ́-(4,6-dihydroxy-1,3-phenylene)diethanone (1) with appropriate aryl-aldehydes, oxidative cyclization of bis-chalcones in presence of iodine gave corresponding flavones (3a-d). The synthesized compounds were evaluated for t...

C-boivinopyranosyl flavones have rarely been isolated from nature. In the search for anti-HBV (hepatitis b virus) constituents of Alternanthera philoxeroides, two new compounds, luteolin-6-C-β-D-boivinopyranosyl-3'-O-β-D-glucopyranoside (1) and chrysoeriol-6-C-β-D-boivinopyranosyl-4'-O-β-D-glucopyranoside (2), along with three known C-boivinopyranosyl flavones (compounds 3-5) were isolated. The...

Chalcone and their heterocycalic analogues are known to posses a broad spectram of biological effects. The present study is devoted to the synthesis of 6-bromo-4-methoxy-4-(substituted phenyl) imino flavones. The newly synthesized compounds were screened for their antimicrobial and antifungal activities. 2-hydroxy-5-bromo-4-methoxychalconeimine on refluxing in DMSO for two hrs in presence of ca...

Two new 2'-oxygenated flavones, 5,2',6'-trihydroxy-7-methoxyflavone (3) and skullcapflavone I 2'-O-beta-D-(4"-E-cinnamyl) glucopyranoside (5), together with three known flavones, 7-O-methylwogonin (1), skullcapflavone I (2) and skullcapflavone I 2'-O-beta-D-glucopyranoside (4) were isolated from the whole plant of Andrographis elongata, and the structures were elucidated by FAB-MS and one- and ...

A series of bis-chalcones (3a-g) and their flavones derivatives (4a-g) were synthesized and evaluated for their antimicrobial activity. Bis-chalcones were prepared by condensing 1,1'-(4,6-dihydroxy-1,3-phenylene)diethanone (2) with appropriate aryl aldehydes following Claisen-Schmidt reaction conditions. Oxidative cyclization of bis-chalcones (3a-g) in DMSO in the presence of iodine furnished f...

We evaluated the antioxidant properties of four main flavones from Scutellaria baicalensis: baicalein, wogonin and their glucuronides - baicalin and wogonoside. We used three in vitro assays: free radical scavenging with 2,2'-diphenylpicrylhydrazyl radical, transition metal ions reducing power by phosphomolybdenum assay and inhibition of the hydroxyl radical-induced peroxidation of linoleic aci...