We studied the effect of cerebellar lesions on the 3-D control of the rotational vestibuloocular reflex (RVOR) to abrupt yaw-axis head rotation. Using search coils, three-dimensional (3-D) eye movements were recorded from nine patients with cerebellar disease and seven normal subjects during brief chair rotations (200 degrees /s(2) to 40 degrees /s) and manual head impulses. We determined the a...

Precision and accuracy of the subjective visual vertical (SVV) modulate in the roll plane. At large roll angles, systematic SVV errors are biased toward the subject's body-longitudinal axis and SVV precision is decreased. To explain this, SVV models typically implement a bias signal, or a prior, in a head-fixed reference frame and assume the sensory input to be optimally tuned along the head-lo...

A class of novel triptycene-derived calix[6]resorcinarene-like hosts have been designed and synthesized, and they are all cis-isomers with fixed cone conformation and can form head-to-head dimeric structures in the solid state.

Downbeat nystagmus (DBN) observed in head-hanging positions, may be of central or peripheral origin. Central DBN positions is mostly due to a disorder the vestibulo-cerebellum, whereas usually attributed canalolithiasis an anterior semicircular canal. Here, we describe atypical case patient who, after head trauma, experienced severe and stereotypic vertigo attacks being placed various positions...

Sound localization in humans relies on binaural differences (azimuth cues) and monaural spectral shape information (elevation cues) and is therefore the result of a neural computational process. Despite the fact that these acoustic cues are referenced with respect to the head, accurate eye movements can be generated to sounds in complete darkness. This ability necessitates the use of eye positi...

In this paper we report the results of an experiment to investigate the emergence of ocular vestibular evoked myogenic potentials (OVEMPs) during the linear vestibular ocular reflex (LVOR) evoked by whole-body vibration (WBV). OVEMP and electrooculogram (EOG) montages were employed to record periocular potentials (POPs) from six subjects during WBV in the nasooccipital (NO) axis over a range of...

Previous experiments have shown that the vestibulo-ocular reflex (VOR) is partially suppressed during large head-free gaze (gaze = eye-in-head + head-in-space) shifts when both the eyes and head are moving actively, on a fixed body, or when the eyes are moving actively and the head passively on a fixed body. We tested, in human subjects, the hypothesis that the VOR is also suppressed during gaz...

BACKGROUND The purpose of this study was to evaluate the biomechanical advantages of medial support screws (MSSs) in the locking proximal humeral plate for treating proximal humerus fractures. METHODS Thirty synthetic left humeri were randomly divided into 3 subgroups to establish two-part surgical neck fracture models of proximal humerus. All fractures were fixed with a locking proximal hume...

Sanders JI, Kepecs A. Choice ball: a response interface for twochoice psychometric discrimination in head-fixed mice. J Neurophysiol 108: 3416–3423, 2012. First published September 26, 2012; doi:10.1152/jn.00669.2012.—The mouse is an important model system for investigating the neural circuits mediating behavior. Because of advances in imaging and optogenetic methods, head-fixed mouse preparati...