نتایج جستجو برای: fibrin fragment d

تعداد نتایج: 646320  

Journal: :Journal of the American College of Cardiology 2002
Sridhar Kamath Andrew D Blann Bernard S P Chin Gregory Y H Lip

OBJECTIVES This study was designed to investigate whether or not combination aspirin-clopidogrel therapy would reduce markers of thrombogenesis and platelet activation in atrial fibrillation (AF), in a manner similar to warfarin. BACKGROUND Dose-adjusted warfarin is beneficial as thromboprophylaxis in AF, but potentially serious side effects and regular monitoring leave room for alternative t...

Journal: :Circulation 1998
J I Weitz B Leslie M Hudoba

BACKGROUND Thrombolytic therapy induces a procoagulant state characterized by elevated plasma levels of fibrinopeptide A (FPA), but the responsible mechanism is uncertain. METHODS AND RESULTS Washed plasma clots were incubated in citrated plasma in the presence or absence of tissue plasminogen activator (t-PA), and FPA generation was monitored as an index of unopposed thrombin activity. FPA l...

Journal: :Biochemical Society transactions 1989
U H Wiese P C Emson R C Sheppard

the molecule(s) recognized by all four of the antibodies are consumed in the clotting process and that this molecule(s) is fibrin(ogen). AHF2: 1 reacted with fibrinogen separated in SDS/polyacrylamide-gel electrophoresis under reducing conditions followed by Western blotting on to nitrocellulose to reveal two bands of molecular mass 60.5 kDa and 64.4 kDa. These bands correspond to the A-a bands...

Journal: :Thrombosis and haemostasis 2016
Sara J Henderson Jing Xia Huayin Wu Alan R Stafford Beverly A Leslie James C Fredenburgh David A Weitz Jeffrey I Weitz

Zinc released from activated platelets binds fibrin(ogen) and attenuates fibrinolysis. Although zinc also affects clot formation, the mechanism and consequences are poorly understood. To address these gaps, the effect of zinc on clot formation and structure was examined in the absence or presence of factor (F) XIII. Zinc accelerated a) plasma clotting by 1.4-fold, b) fibrinogen clotting by 3.5-...

D-dimer is a soluble fibrin degradation product deriving from the plasmin-mediated degradation of cross-linked fibrin. D-dimer can hence be considered a biomarker of activation of coagulation and fibrinolysis, and it is routinely used for ruling out venous thromboembolism (VTE). D-dimer is increasingly used to assess the risk of VTE recurrence and to help define the uoptimal duration of anticoa...

Journal: :Thrombosis and haemostasis 2001
G D Lowe A Rumley P M Sweetnam J W Yarnell J Rumley

We have previously reported that plasma fibrin D-dimer (a marker of turnover of cross-linked fibrin) showed a strong and independent association with incident ischaemic heart disease (IHD) in the Caerphilly Study cohort of 1,998 men aged 49-65. To establish the specificity of this finding, we assayed plasma samples from this cohort with a more specific assay for fibrin D-dimer: this showed an a...

2011
Takeshi Morii Kazuo Mochizuki Takashi Tajima Shoichi Ichimura Kazuhiko Satomi

BACKGROUND Plasma d-dimer levels have been associated with the status of tumor progression or oncological outcomes in cancer. Although there are many evidences suggesting the involvement of procoagulant trend in musculoskeletal sarcoma, no clinical data on d-dimer levels and oncological outcome of musculoskeletal sarcoma has been reported. METHODS In this study, we included a total of 85 pati...

Journal: :Chest 2004
Jose M Querol-Ribelles Jose M Tenias Enric Grau Jose M Querol-Borras Jose L Climent Emilio Gomez Isidoro Martinez

STUDY OBJECTIVES The aim of this study was to investigate the prognostic value of plasma d-dimer levels in patients with community-acquired pneumonia (CAP). DESIGN Prospective observational study. SETTING Hospital Lluis Alcanyis of Xativa, Spain. PATIENTS Consecutive adult patients admitted to the hospital with CAP from January 2000 to October 2002. MEASUREMENTS AND RESULTS A total of 3...

2017
Se Jeong Kim Hyo Jeong Ahn Jung Yeon Park Byoung Jae Kim Kyu Ri Hwang Taek Sang Lee Hye Won Jeon Sun Min Kim

Objective Pregnancy is a major risk factor of thromboembolism, and the patients with preeclampsia (PE) are known to have higher risk of thromboembolic complications than normal pregnant women. D-dimer is a well-established laboratory marker for the screening of venous thromboembolism (VTE), but the concentrations of d-dimer tend to increase physiologically in pregnant women throughout the gesta...

Journal: :The Journal of biological chemistry 1985
C Southan E Thompson M Panico T Etienne H R Morris D A Lane

The C-terminal region of the fibrinogen gamma chain is known to participate in several functional interactions including fibrin polymerization. This part of the molecule is retained on the gamma chain of fragment D (FgD) when fibrinogen is digested by plasmin in the presence of calcium to produce the fragment D-fragment E (FgD X FgE) complex but is lost if FgD is prepared in the absence of calc...

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