The effect of intracerebroventricular administration of chlorpromazine (CPZ) on the serum level of free fatty acid (FFA) was studied in rats. Injection of CPZ into the lateral ventricle caused a transient decrease in serum FFA, showing the lowest level after 30 min. This decrease in serum FFA caused by CPZ was significantly inhibited by simultaneous injection of dopamine or apomorphine, althoug...

Segments of epididymal adipose tissue from normal male rats were incubated with micromolar concentrations of colchicine for different periods of time up to 4 hr, and the mobilization of free fatty acids (FFA) was measured during a subsequent reincubation. Although pretreatment with colchicine did not alter basal unstimulated FFA release, mobilization of FFA in the presence of epinephrine or the...

The mechanism by which FFA metabolism inhibits intracellular insulin-mediated muscle glucose metabolism in normal humans is unknown. We used the leg balance technique with muscle biopsies to determine how experimental maintenance of FFA during hyperinsulinemia alters muscle glucose uptake, oxidation, glycolysis, storage, pyruvate dehydrogenase (PDH), or glycogen synthase (GS). 10 healthy volunt...

MILLER,HARVEY I., KEUKY.YUM,AND BEATRICE C.DURHAM. Myocardial free fatty acid in unanesthetized dogs at rest and during exercise. Am. J. Physiol. 220(3) : 589-596. 197 1 .-Myocardial free fatty acid (FFA) metabolism was studied in unanesthetized dogs at various plasma FFA concentrations. Exercise and norepinephrine (NE) infusion were used to raise the FFA level while glucose infusion was used t...

The free fatty acid (FFA) content in dry cocoa beans is expected to be less than 1.0% to meet the acceptable level of 1.75% in cocoa butter. This study therefore investigates the impact of insect infestation on FFA formation in raw cocoa beans in storage from Ghana and Côte d’Ivoire. Hence, the effect of storage management on FFA content in dry cocoa beans is very important. The effect of insec...

OBJECTIVE Although elevated free fatty acid (FFA) levels in obesity have been considered to be of importance for insulin resistance, a recent meta-analysis suggested normal FFA levels in obese subjects. We investigated fasting circulating FFA and glycerol levels in a large cohort of non-obese and obese subjects. METHODS Subjects recruited for a study on obesity genetics were investigated in t...

OBJECTIVES Due to their role in inflammatory metabolic diseases, we hypothesised that free fatty acids (FFA) are also involved in inflammatory joint diseases. To test this hypothesis, we analysed the effect of FFA on synovial fibroblasts (SF), human chondrocytes and endothelial cells. We also investigated whether the toll-like receptor 4 (TLR4), which can contribute to driving arthritis, is inv...

Lipolysis may regulate liver free fatty acid (FFA) uptake and triglyceride accumulation; both are potential causes of insulin resistance and liver damage. We evaluated whether 1) systemic FFA release is the major determinant of liver FFA uptake in fasting humans in vivo and 2) the beneficial metabolic effects of FFA lowering can be explained by a reduction in liver triglyceride content. Sixteen...

Human platelets take up and metabobound FFA. These findings suggested Iize long-chain free fatty acids (FFA). that a large portion of the platelet FFA Experiments in which platelets were uptake might be associated with the loaded with ‘4C-palmitate, homogenplatelet surface. Radioautography with ized, and then fractionated indicated electron microscopy using 3H-palmilarge amounts of membrane-bou...

Studies with Ehrlich ascites tumor cells showed that small decreases in the pH of the incubation medium from 7.4 increase the magnitude of incorporation of free fatty acid (FFA) into the cells from an albumin solution. A similar effect occurred when rabbit erythrocytes, rat heart slices, or rat liver slices were incubated with FFA-bovine albumin solutions and when tumor cells were incubated wit...