BACKGROUND Despite advances in the medical care of renal transplant recipients which have led to an improvement in allograft survival, renal allograft rejection is still a major obstacle to successful organ transplantation. Understanding the mechanisms contributing to allograft rejection will be of great importance for the development of efficient antirejection strategies. OBJECTIVE The aim o...

19 young children (less than 5 years old) have received 31 renal transplants from 4 live relatives and 27 cadaver donors. The 2-year allograft survival rate for the patients receiving their 1st allograft from the 4 live donors was 75 +/- 22% while for the patients receiving their 1st allograft from 15 cadaver donors was 26 +/- 11%. 10 children are currently surviving with functioning allographs...

A two-element protocol consisting of one donor-specific transfusion (DST) plus a brief course of anti-CD154 mAb greatly prolongs the survival of murine islet, skin, and cardiac allografts. To study the mechanism of allograft survival, we determined the fate of tracer populations of alloreactive transgenic CD8+ T cells in a normal microenvironment. We observed that DST plus anti-CD154 mAb prolon...

background: correlations between bone marrow, heart, kidney, liver, skin and lung transplant rejection or survival with human cytokine gene polymorphisms have been described. there are also reports about the role of cytokines and tumor necrosis factors-alpha (tnf-α) on corneal transplant in animal models. further studies are needed to clarify the role of cytokines in corneal allograft rejection...

OBJECTIVE To determine whether kidney transplants performed during a weekend had worse outcomes than those performed during weekdays. DESIGN Retrospective national database study. SETTING United Network for Organ Sharing database of the USA. PARTICIPANTS 136,715 adult recipients of deceased donor single organ kidney transplants in the USA between 4/1994 and 9/2010. MAIN OUTCOME MEASURES...

Treatment of adult mice of three strains with mini mally carcinogenic doses of urethan caused an impair ment of cellular immunity as measured by prolongation of allograft survival. This effect was only detectable at the highest dose of urethan tested (150 mg/mouse) and was confined to the weaker strain combinations examined for allograft prolongation. Newborns appeared to be more susceptible to...

Treatment of adult mice of three strains with mini mally carcinogenic doses of urethan caused an impair ment of cellular immunity as measured by prolongation of allograft survival. This effect was only detectable at the highest dose of urethan tested (150 mg/mouse) and was confined to the weaker strain combinations examined for allograft prolongation. Newborns appeared to be more susceptible to...

BACKGROUND Living kidney donor pools are expanding with the use of "medically complex" donors. Whether or not to include cigarette smokers as living kidney donors remains unclear. The aim of this study was to determine the relationship between donor smoking and recipient outcomes. We hypothesized that donor smoking would increase donor complications and decrease allograft and recipient survival...

Background: There is no consensus regarding the best method of reconstruction in pediatric population following thewide resection of malignant bone tumors. More exploration of the complications of osteoarticular reconstruction leads toless existing controversy of this type of reconstruction, which is the main point of this article.Methods: Long-term outcomes and complications of osteoarticular ...