AIM The aim of this study was to evaluate TSPY (testis specific protein on the Y chromosome) gene and 5'UTR (UnTranslated Region) polymorphisms in men with impaired fertility compared to fertile controls. METHODS We analyzed 72 infertile men and 31 fertile controls usingconventional sequencing analysis to find crucial SNPs (single nucleotide polymorphism) and other changes. RESULTS The most...

BACKGROUND The available evidence on the role of obesity and body mass index (BMI) on male infertility has been controversial or inconclusive to some extent. OBJECTIVES The aim of this study was to investigate the role of BMI on some male-fertility laboratory indicators both among infertile and fertile men in an Iranian population. METHODS AND MATERIALS A total of 159 male patients who had ...

The aim of this study was to assess the level of malondialdehyde (MDA) in the seminal plasma of infertile men and to highlight a relationship between the level of MDA and semen parameters. Eighty-one infertile patients were divided into groups according to their clinical diagnosis: genitourinary infections, varicocele and idiopathic infertility. Semen quality was assessed by light and transmiss...

A case-control study was conducted to examine whether occupational or environmental exposures, particularly to heavy metals, are associated with male infertility in Lebanon, a war-torn country with a history of environmental degradation. Seventy-four infertile cases and 76 fertile controls were selected from 2 major fertility clinics in Beirut. Data collection involved risk-factor interviews, s...

Aim. This study aimed to assess seminal miRNA relationship with seminal apoptotic markers and oxidative stress (OS) in infertile men associated with varicocele (Vx). Methods. In all, 220 subjects were divided into the following groups: fertile normozoospermic men, fertile normozoospermic men with Vx, infertile oligoasthenoteratozoospermic (OAT) men without Vx, and infertile OAT men with Vx. The...

OBJECTIVE To evaluate levels of sperm nuclear DNA damage in infertile men with normal and abnormal standard semen parameters. DESIGN Prospective study. SETTING Male infertility clinic. PATIENT(S) Ninety-two men seeking infertility treatment and 16 fertile volunteers. INTERVENTION(S) Standard semen analysis was performed according to the World Health Organization guidelines. MAIN OUTCO...

background: human papillomaviruses (hpvs) are the most common viruses which can be sexually transmitted. they can cause different malignancies in asymptomatic women. the association of hpvs with infertility among men and women is controversial. in the current study, the authors compared the frequency of hpvs in fertile and infertile women in the city of mashhad. materials and methods: in the pr...

objective: globozoospermia is a rare type of teratozoospermia with incidence of 0.1% among infertile individuals. phospholipase c zeta (plcζ) and postacrosomal sheath ww domain binding protein (pawp) are the main candidates in sperm taking responsibility for oocyte activation during fertilization. therefore, we aimed to evaluate the expression of these two genes at rna and protein levels in glo...

AIM To complete comprehensive haplotype analysis of USP26 for both fertile and infertile men. METHODS Two hundred infertile men with severe oligospermia or non-obstructive azoospermia were subjected to sequence analysis for the entire coding sequences of the USP26 gene. Two hundred men with proven fertility were genotyped by primer extension methods. Allele/genotype frequencies, linkage diseq...