a solid state fermentation method was used to utilize wheat straw as substrates for citric acid production by using aspergillus niger atcc 9142. the plackett burman design (pbd) of experiments was used to test the relative importance of the variables affecting production such as moisture content, age of spore, inoculum size, initial ph of substrate, methanol concentration, incubation temperatur...

An actinomycete, isolated from a soil sample from Ontario, Canada, was studied taxonomically and named Actinosporangium bohemicum sp. nov. strain C-36,145. This strain was found to produce a complex mixture of e-pyrromycinone glycosides having antitumor properties. Marcellomycin, a member of this complex, was selected for further study. Conditions for production of this antibiotic were develope...