Accurate real-time process control is necessary to increase process efficiency, and optical sensors offer a competitive solution because they provide diverse system information in a noninvasive manner. We used an innovative scattered light sensor for the online monitoring of biomass during lactic acid production in a membrane bioreactor system because biomass determines productivity in this typ...

A robust strain of the species Saccharomyces cerevisiae CGMCC1949 was screened and identified, and advanced solid state fermentation (ASSF) technology for fuel ethanol production from sweet sorghum stalks was thus developed. The fermentation time was shortened to less than 30 h, and ethanol yield was 92% of its theoretical maximum. And in the meantime, the cost-effective storage was established...

Mortierella alpina (M. alpina) is well known for arachidonic acid (ARA) production. However, low efficiency and unstableness are long existed problems for industrial production of ARA by M. alpina due to the lack of online regulations. The aim of the present work is to develop an online-regulation strategy for efficient and stable ARA production in industry. The strategy was developed in 50 L f...

In the present work, the effects of dual impeller configurations comprising of Rushton turbine (RT) and Concave-bladed disk turbine (CD-6) on the oxygen transfer profile and fermentation performance of kojic acid production by Aspergillus flavus Link 44-1 was investigated. Batch cultivations of A. flavus Link 44-1 were performed in 2 L stirred tank bioreactor. The fermentations were conducted u...

KRASTANOV, A., A. GOVINDARAJAN and D. DANIEL, 2008. Studies on lipase fermentation using Candida cylindracea NRRL Y-17506 in a stired tank bioreactor. Bulg. J. Agric. Sci., 14: 290-299 Lipase is an enzyme of considerable commercial and industrial importance. The major applications of lipase are in the fat and oleochemical, food and dairy, textile, detergent, cosmetics, tea processing, pulp and ...

Bacteria, fungi and protozoa inhabiting the rumen, the largest chamber of the ruminants' stomach, release large quantities of hydrogen during the fermentation of carbohydrates. The hydrogen is used by coexisting methanogens to produce methane in energy-yielding processes. This work shows, for the first time, a fundamental possibility of using a hydrogen-rich fermentation gas produced by selecte...

In this work, Evolutionary Algorithms (EAs) are used to achieve optimal feedforward control in a recombinant bacterial fed-batch fermentation process, that aims at producing a bio-pharmaceutical product. Three different aspects are the target of the optimization procedure: the feeding trajectory (the amount of substrate introduced in a bioreactor per time unit), the duration of the fermentation...

In this study the effect of inoculum size, volume of fermentation medium and aeration rate was analyzed for UV mutated strain of Aspergillus niger AN-14 regarding enhanced production of glucose oxidase. UV treated 10 variants showing positive variations from parent strain were isolated and analyzed for glucose oxidase production using shake flask fermentation. Mutant strain AN-14 gave maximum p...

A method for formalization and analytical determination of the kinetic parameters of continuous alcohol fermentation in a reactor and in a cascade of reactors with ideal mixing was discussed in the present work. A fluidized bed bioreactor with immobilized yeast with elucidated structure of the flows was used. The method of formalization of the process kinetics involved two steps – determination...

Nowadays, vinegar is industrially produced by mesophilic acetic acid bacteria (AAB). However, temperature fluctuation during acetous fermentation is inevitable, and may cause process disturbances. This can be mostly avoided using thermo-tolerant AAB. The main purpose of the present study was to isolate thermo-tolerant AAB. Fermentation performances were then evaluated. Twenty-eight different is...