objective: n-nitroso-n-methylurea (nmu) induces breast cancer in rodents, particularly in rats. this model of breast cancer is very similar to human breast cancer. as a continuation of our recent work, we investigated the expressions of cyclin d1 and p21 in nmu-induced breast cancer of wistar albino rats. materials and methods: in this experimental study, mammary carcinoma was induced in female...

Effect of Allium sativum Linn. (Alliaceae) (Raw Garlic Extract (RGE)) was studied on free amino acids (FAA) level in female albino rats. The garlic extract was tested in three different doses 1ml, 2ml and 4ml/ kg body weight daily as low, medium and high dose respectively for a period of 7, 14, 21 and 28 days. The significant (P<0.01) increase in Free amino acid (FAA) level was observed when ra...

The domestication process of the laboratory rat has been going on for several hundred generations in stable environmental conditions, which may have affected their physiological and behavioural functions, including their circadian system. Rats tested in our ethological experiments were laboratory-bred wild Norway rats (WWCPS), two strains of pigmented laboratory rats (Brown Norway and Long Evan...

JOLLY,DENNIS W., CAROLYN CRAIG, ANDTHOMAS E. NELSON, JR. Estrogen and prothrombin synthesis: effect of estrogen on absorption of vitamin K,. Am. J. Physiol. 232(l): H12H17, 1977 or Am. J. Physiol: Heart Circ. Physiol. l(1): H12H17, 1977. -Intact male and female albino rats fed a vitamin K-deficient diet develop a plasma prothrombin-proconvertin deficiency. Male rats respond with a precipitous d...

Intact male and female albino rats fed a vitamin K-deficient diet develop a plasma prothrombin-proconvertin deficiency. Male rats respond with a precipitous drop to approximately 20-30% of normal plasma levels within 2-5 days, whereas female rats respond at a slower rate. Ethynylestradiol, 5-10 mug/day, or castration, reduces the progressive decline of plasma prothrombin-proconvertin seen in no...

INTRODUCTION Globally, the prevalence of overweight and obesity is increasing, predisposing females to health hazards including compromised reproductive capacity. Our objective was to investigate the effect of ad libitum, isocalorically and hypocalorically restricted high-fat diet (HFD) feeding on reproductive function in diet-induced obese female rats. MATERIAL AND METHODS Twenty female albi...

The effects of exercise on the severity of isoproterenol-induced myocardial infarction were studied in female albino rats of 20,40,60 and 80 weeks of age. The rats were trained to swim for a specific duration and for a particular period. The occurrence of infarcts were confirmed by histological methods. Elevations in the serum GOT and GPT were maximum in the sedentary-isoproterenols and minimum...