Background and aim: Cicatrical alopecia refers to lesions associated with permanent destruction of hair follicles. Several diseases such as folliculitis decalvans, lichenplanopilaris (LPP) and discoid lupus erythematosus (DLE) may result in cicatricial alopecia. Since cicatricial alopecia is scarring and affects both the appearance and psychosocial behaviours of the patients and also it c...

Reports research findings specifically examining the critical initial stage of engaging older residents in community development activities and the practice of community development with older adults in multi-cultural settings. In its Global Age Friendly Cities project, the World Health Organization identifies social engagement as one indicator of an Age Friendly Community. Such engagement can ...

In this study, the effects of acetylsalicylic acid (ASA), the active agent in aspirin, and acetaldehyde (AcH), an intermediate metabolite in alcohol metabolism, on life span and some developmental characteristics of Drosophila melanogaster are investigated. Substance administration was done on adult Drosophila through feeding. The effects were investigated using both ASA and AcH individually (A...

Psychiatric functioning and disability have historically been considered separate from the broader disability field and have been measured differently than other medical conditions. This paper provides an overview of the current concepts and international advances in the classification of psychiatric disability and explores the controversies and goals within the proposed systems. It highlights ...

Mechanisms that ensure and maintain the stability of genetic information are fundamentally important for organismal function and can have a large impact on disease, aging, and life span. While a multi-layered cellular apparatus exists to detect and respond to DNA damage, various insults from environmental and endogenous sources continuously affect DNA integrity. Over time this can lead to the a...

Drosophila melanogaster mutants with deficient kynurenine (KYN) formation from tryptophan (TRP) have longer life span than wild type flies. Administration of alpha-methyl-TRP and 5-methyl-TRY, the inhibitors of TRP-KYN metabolism, prolonged life span in wild-type flies. Both inhibitors are not available for human use. Berberine, an isoquinoline alkaloid isolated from Berberis aristata, is known...

The scientific debates on the future of human life span and its possible biological limits revealed a great need for direct identification of longevity boundaries, if they really exist. The key question posed in this study is as follows: how can we possibly determine the age when human longevity starts? To address this problem, we studied the familial transmission of human life span from parent...

BACKGROUND Little is known about the number or chromosomal location of genetic loci that might identify individuals destined to have a long life span. Analysis of gene/life span associations in mice, which are short-lived compared to humans, might provide guidance for an analysis of the genetic basis of life span in humans. METHODS A group of 144 genetically heterogeneous mice, produced by a ...