نتایج جستجو برای: fed batch process

تعداد نتایج: 1406141  

Journal: :Analytical and bioanalytical chemistry 2011
Catherine L Winder Robert Cornmell Stephanie Schuler Roger M Jarvis Gill M Stephens Royston Goodacre

Fourier transform infrared (FT-IR) spectroscopy was employed as a rapid high-throughput phenotypic typing technique to generate metabolic fingerprints of Escherichia coli MG1655 pDTG601A growing in fed-batch culture, during the dioxygenase-catalysed biotransformation of toluene to toluene cis-glycol. With toluene fed as a vapour, the final toluene cis-glycol concentration was 83 mM, whereas the...

2011
J. Chen

In this paper, a novel monitoring method for the repetitive batch operation with two-dimensional dynamic behavior is proposed. It combines dynamic multiway principal component analysis (DMPCA) and hidden segmental semi-Markov models (HSMM) to resolve the problem caused by the two-dimensional behavior of batch processes. DMPCA utilizes the batch-to-batch dynamic characteristics and eliminates th...

Journal: :iranian journal of biotechnology 2009
hosein ghahremani mahmood reza pishvaie manouchehr vossoughi ali akbar seyfkordi

modeling of fermentation processes is so complicated and uncertain; therefore it is necessary to provide a robust and appropriate dynamic optimization method. in order to obtain the maximum amount of yeast (saccharomyces cerevisiae), the bioreactor must be operated under optimal conditions. to determine substrate feeding in a fed-batch bioreactor, a simulated annealing (sa) approach was examine...

2012
Zhou Jiang Kurt Droms Zhaohui Geng Susan Casnocha Zhihua Xiao Steve Gorfien Scott J. Jacobia

level: intermediAte Most biopharmaceutical production platforms are based on fed-batch cell culture protocols, which can support high volumetric productivity while maintaining low operational complexity (1). The industry is interested in developing or refining high-titer cell culture processes to meet increasing market demands and reduce manufacturing costs (2). Although advancements in cell en...

2013
Judith Wahrheit Averina Nicolae Elmar Heinzle

Background Glutamine metabolism represents one of the major targets in metabolic engineering and process optimization due to its importance as cellular energy, carbon and nitrogen source. Metabolic flux analysis represents a powerful method to investigate the physiology and metabolism of cells [1]. Classical metabolic flux analysis methods require steady state conditions. However, industrially ...

2005
A. B. Neto D. B. Hirata L. C. M. Cassiano Filho C. Bellão A. C. Badino

Clavulanic acid (CA) is a potent inhibitor of β-lactamases, enzymes that are responsible for the hydrolysis of β-lactam antibiotics. It is a secondary metabolite produced by the filamentous aerobic bacterium Streptomyces clavuligerus in submerged cultivations. In the present work clavulanic acid production in batch, fed-batch and continuous bioreactors was studied with the objective of increasi...

Journal: :Biotechnology progress 2004
Longan Shang Seong Chun Yim Hyun Gyu Park Ho Nam Chang

Several important properties of poly(3-hydroxybutyric-co-3-hydroxyvaleric acids) (P(3HB-co-3HV) depend mainly on the HV unit fraction of the copolymer. Sequential and simultaneous feeding of glucose and valerate were employed to produce P(3HB-co-3HV) in a fed-batch culture of Ralstonia eutropha, and the effects of feeding models on the cell growth, 3HV unit fraction, and copolymer productivity ...

1996
Chungmin Chen Kenneth Salem Miron Livny

We present the Distributed Batch Controller (DBC), a system built to support batch processing of large scientiic datasets. The DBC implements a federation of autonomous workstation pools, which may be widely-distributed. Individual batch jobs are executed using idle workstations in these pools. Input data are staged to the pool before processing begins. We describe the architecture and implemen...

Journal: :Applied and environmental microbiology 1997
F Wang S Y Lee

Alcaligenes latus has been known to produce poly(3-hydroxybutyrate) (PHB) in a growth-associated manner even under nutrient-sufficient conditions. However, the PHB content obtained by fed-batch culture was always low, at ca. 50%, which makes the recovery process inefficient. In this study, the effect of applying nitrogen limitation on the production of PHB by A. latus was examined. In flask and...

Journal: :Chemical Engineering Communications 2021

Hydrogen has received considerable attention as a sustainable energy source to the future and biological hydrogen production been gaining consideration potential method. One microorganism that produces is nitrogen-fixing cyanobacterium Cyanothece sp. ATCC 51142, which stands out for its rate of production. However, there are still some challenges understanding improving process by this cyanobac...

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