Inducing high levels of reactive oxygen species (ROS) inside tumor cells is a cancer therapy method termed chemodynamic (CDT). Relying on delivery Fenton reaction promoters such as Fe2+, CDT takes advantage overproduced ROS in the microenvironment. We developed peptide-H2S donor conjugate, complexed with AAN-PTC–Fe2+. The AAN tripeptide was specifically cleaved by legumain, an enzyme overexpres...

A cytosolic protein factor (ferroactivator) facilitates the activation of phosphoenolpyruvate carboxykinase by ferrous ions (Bentle, L. A., and Lardy, H. A. (1977) J. Biol. Chem. 252, 1431-1440). We have extended our studies on the interaction of Fe2+ with this enzyme to establish the conditions under which it is an activator or an inhibitor. Preincubation of phosphoenolpyruvate carboxykinase w...

Background & Aims of the Study: Pharmaceutical compounds have a variety of forms and applications. Specific amounts of toxic organic compounds in the process of their manufacturing and utilization cause environmental pollution problems. So, degradation and removal these compounds are necessary. The aim of this paper is the study photocatalytic degradation of ciprofloxacin drug in aqueous soluti...

Daniellia oliveri is one of the most extensively utilized medicinal plants in Nigeria and some West African countries for treatment various ailments. In present study, GC-MS profiles effect ethanolic extracts stem bark leaves on lipid peroxidation, Na+/K+-ATPase activity thiols status H2O2 Fe2+ (fenton reaction) assaulted cerebral hepatic tissue homogenates was investigated. The were extracted ...

Abstract Widely used in chemical product manufacture, 1,4-dioxane is one of the emerging contaminants, and it poses great risk to human health ecosystem. The aim this study was degrade 1,4-dioxiane using a pulsed switching peroxi-coagulation (PSPC) process. electrosynthesis H2O2 on cathode Fe2+ production iron sacrifice anode were optimized enhance degradation. Under current densities 5 mA/cm2 ...

Due to its high oil content, the discharge of bilge water from ships is one most important pollutants in marine ecosystem. In this research, we investigated treatment for Haydarpasa Waste Collection Plant by Fenton oxidation followed granular activated carbon (GAC) adsorption. We applied following optimum operational conditions oxidation: [Fe2+]: 6 mM; [H2O2]: 30 and ratio [Fe2+]/[H2O2]: 1/5. A...

The anticancer drug adriamycin binds iron and these complexes cycle to reduce molecular oxygen (Zweier, J. L. (1984) J. Biol. Chem. 259, 6056-6058). Optical absorption, EPR, and Mössbauer spectroscopic data are correlated with polarographic O2 consumption and chemical Fe2+ extraction measurements in order to characterize each step in this cycle. Fe3+ binds to adriamycin at physiologic pH formin...

The active site of superoxide reductase SOR consists of an Fe2+ center in an unusual [His4 Cys1] square-pyramidal geometry. It specifically reduces superoxide to produce H2O2. Here, we have reacted the SOR from Desulfoarculus baarsii directly with H2O2. We have found that its active site can transiently stabilize an Fe3+-peroxo species that we have spectroscopically characterized by resonance R...