Femtosecond to picosecond dynamics of enzyme active sites is relatively unknown. With the advent of two-dimension infrared spectroscopy, it is now possible to characterize thermally activated motions at this time scale in functionally relevant enzyme complexes. We present a series of measurements on complexes of formate dehydrogenase (FDH) using transitional-state analog inhibitor azide as a re...

Familial dyslipidemic hypertension (FDH) Is a syndrome recently described from sibshlps selected for early familial hypertension and found to have one or more of three fasting llpld abnormalities [high trlglycerldes, low high density lipoprotein (HDL) cholesterol, high low density lipoprotein (LDL) cholesterol]. In further analyses of these same 131 hypertensive subjects, apolipoprotein A-l and...

The Full Domain Hash (FDH) scheme is a RSA-based signature scheme in which the message is hashed onto the full domain of the RSA function. The FDH scheme is provably secure in the random oracle model, assuming that inverting RSA is hard. In this paper we exhibit a slightly different proof which provides a tighter security reduction. This in turn improves the efficiency of the scheme since small...

10-Formyltetrahydrofolate dehydrogenase (FDH) is composed of three domains and possesses three catalytic activities but has only two catalytic centers. The amino-terminal domain (residue 1-310) bears 10-formyltetrahydrofolate hydrolase activity, the carboxyl-terminal domain (residue 420-902) bears an aldehyde dehydrogenase activity, and the full-length FDH produces 10-formyltetrahydrofolate deh...

Focal dermal hypoplasia (FDH) is a rare disorder of the mesodermal and ectodermal tissues. Here we present an eight-year-old female known to have FDH who presents with poor weight gain and dysphagia. She was diagnosed with multiple esophageal papillomas and eosinophilic esophagitis. She was successfully treated with argon plasma coagulation and ingested fluticasone propionate, which has not bee...

In this paper, we aim to overcome three major shortcomings of the FDH (Free Disposal Hull) directional distance function through developing two new, named Linear and Fractional CDFDH, complete FDH measures of efficiency. To accomplish this, we integrate the concepts of similarity and FDH directional distance function. We prove that the proposed measures are translation invariant and unit invari...

This paper deals with evaluating congestion in free disposal hull (FDH) models. There are several approaches in data envelopment analysis (DEA) literatures which discuss the theory and application of congestion. However, almost all of these approaches considered convex DEA technologies. So, in the case of nonconvex technologies, including FDH technology, this field is almost nil. This paper mak...

Enzymes have become important tools in several industries due to their ability to produce chirally pure and complex molecules with interesting biological properties. The NAD(+)-dependent LDH (lactate dehydrogenase) [bsLDH [Geobacillus stearothermophilus (formerly Bacillus stearothermophilus) LDH] from G. stearothermophilus and the NAD(+)-dependent FDH (formate dehydrogenase) [cmFDH (Candida met...

To investigate the role of thyroxine-binding globulin (TBG) and albumin in the availability of thyroid hormones to peripheral tissues, comprehensive kinetic studies of thyroxine (T4) and triiodothyronine (T3) were carried out in eight subjects with familial dysalbuminemic hyperthyroxinemia (FDH), in four subjects with inherited TBG excess, and in 15 normals. In high-TBG subjects, the reduction ...