Erythropoiesis may be limited by absolute or functional iron deficiency or when chronic inflammatory conditions lead to iron sequestration. Intravenous iron may be indicated when oral iron cannot address the deficiency. Ferric carboxymaltose (FCM) is a nondextran iron preparation recently approved in the United States for intravenous treatment of iron deficiency anemia (IDA) in adult patients w...

There is limited safety information about ferric carboxymaltose (FCM), a new intravenous iron preparation. This randomized, crossover study compared the safety and tolerability of double-blinded intravenous doses of FCM or placebo in patients with iron deficiency anemia. Subjects (559) with iron deficiency anemia received a dose of either FCM (15 mg/kg, maximum 1000 mg) over 15 minutes or place...

OBJECTIVE An excess of metalloproteinases (MMPs) over tissue inhibitors of metalloproteinases (TIMPs) may favor atherosclerotic plaque rupture. We compared TIMP levels in nonfoamy and foam-cell macrophages (FCM) generated in vivo. METHODS AND RESULTS In vivo generated rabbit FCM exhibited 84% reduced TIMP-3 protein compared to nonfoamy macrophages, and immunocytochemistry revealed a TIMP-3 ne...

OBJECTIVE To improve the quality of expectation maximizing (EM) for brain image segmentation, and to evaluate the accuracy of segmentation results. METHODS This brain segmentation study was conducted in Universiti Putra Malaysia in Serdong, Malaysia between February and November 2010 on simulated and real images using novel improvement for EM. The EM-1 (proposed algorithm) was compared with n...

BACKGROUND Ferric carboxymaltose (FCM) and iron isomaltoside 1000 (IIM) are increasingly used because they allow correction of severe iron deficiency in a single infusion. A transient decrease in serum phosphate concentrations is a frequent side effect of FCM. AIM To characterize this adverse event and search for its predictors in a gastroenterology clinic patient cohort. METHODS Electronic...

This work develops a knowledge based system to autonomous navigation using Fuzzy Cognitive Maps (FCM). A new variant of FCM, named Dynamic-Fuzzy Cognitive Maps, (D-FCM) is used to model decision tasks and/or make inference in the robot or mobile navigation. Fuzzy Cognitive Maps is a tool that modeling qualitative structured knowledge way through concepts and causal relationships. The proposed ...

 This work develops a knowledge based system to autonomous navigation using Fuzzy Cognitive Maps (FCM). A new variant of FCM, named Event Driven-Fuzzy Cognitive Maps, (ED-FCM) is used to model decision tasks and/or make inference in the robot or mobile navigation. Fuzzy Cognitive Maps is a tool that modeling qualitative knowledge in minds maps structured way through concepts and causal relatio...

Image segmentation is a vital part of image processing. Segmentation has its application widespread in the field of medical images in order to diagnose curious diseases. The same medical images can be segmented manually. But the accuracy of image segmentation using the segmentation algorithms is more when compared with the manual segmentation. In the field of medical diagnosis an extensive dive...

OBJECTIVE To analyse how DNA ploidy and S-phase fraction (SPF) by flow cytometry (FCM) and an optimised fully automatic DNA image cytometer (ICM) correlate with grade in TaT1 urothelial cell carcinomas (UC) of the urinary bladder. MATERIALS AND METHODS Two-hundred-and twenty-eight consensus cases were analysed. Single cell suspensions were stained (DAPI for FCM, Feulgen for ICM). There was en...