Pymatuning Lake, located on the Pennsylvania/Ohio border, is noted for the large numbers of bread-eating carp that frequent the Linesville Causeway "carp bowl" from May to November. Carp were trapped in 1952 and 1984 at the carp bowl, tagged, and relocated varying distances away from the bowl in Sanctuary, Middle, and Lower lakes. Carp traversed the return distances of up to 9 km in less than 4...

Koi herpesvirus (KHV) has a diameter of 170– 230 nm and possesses a double-stranded DNA genome (Pokorova, Vesely, Piackova, Reschova & Hulova 2005). KHV was first discovered in the USA in 1998, followed by outbreaks in koi, Cyprinus carpio koi and common carp, C. carpio carpio, in Israel and the USA (Hedrick, Gilad, Yun & Spangenberg 2000). The virus subsequently spread to numerous countries wo...

Doxorubicin (Adriamycin) is an effective anti-cancer drug, but its clinical usage is limited by a dose-dependent cardiotoxicity characterized by widespread sarcomere disarray and loss of myofilaments. Cardiac ankyrin repeat protein (CARP, ANKRD1) is a transcriptional regulatory protein that is extremely susceptible to doxorubicin; however, the mechanism(s) of doxorubicin-induced CARP depletion ...

BACKGROUND CARP-1/CCAR1, a perinuclear phospho-protein, regulates signaling by adriamycin, steroids, or growth factors. However, intracellular events that regulate CARP-1-dependent cell growth are not fully understood. RESULTS Here we investigated whether CARP-1 is involved in signaling induced by the protein kinase A inhibitor H89. Treatments of human breast cancer cells with H89 resulted in...

The grass carp (Ctenopharyngodon idella) is one of the most important freshwater fish species in China and the world; grass carp production accounts for about 16% of the world’s total freshwater aquaculture [1]. In 2015, Wang et al. performed whole-genome sequencing and de novo assembly for a female (0.9 Gb) and male grass carp (1.07 Gb) by using the shotgun sequencing strategy [2]. Based on th...

The cDNAs encoding glutathione peroxidase (GPx) were cloned and sequenced from the liver of three Chinese carps with different tolerance to hepatotoxic microcystins, phytoplanktivorous silver carp (Hypophthalmichthys molitrix) and bighead carp (Aristichthys nobilis), and herbivorous grass carp (Ctenopharyngodon idellus). Using genome walker method, a 750 bp 5'-flanking region of the silver carp...

In this study, we report the complete mitochondrial DNA (mtDNA) sequences of the allotetraploid and triploid crucian carp and compare the complete mtDNA sequences between the triploid crucian carp and its female parent Japanese crucian carp and between the triploid crucian carp and its male parent allotetraploid. Our results indicate that the complete mtDNA nucleotide identity (98%) between the...

Increasing numbers of hatchery-produced fish entering marine environments has caused concern over potential fitness depressions in wild populations, yet no study has addressed the likelihood of hybridisation between farmed and wild marine fish. Escape rates of Atlantic cod Gadus morhua L. from commercial net pens have been substantial and there is a risk of interbreeding between depleted local ...

BACKGROUND Anti-carbamylated protein (anti-CarP) antibodies have recently been reported to occur in around 45% of rheumatoid arthritis (RA) patients and to have prognostic and diagnostic properties. At present, the breadth and molecular make-up of the anti-CarP antibody response is ill defined. To understand the anti-CarP antibody immune response and potential immune effector mechanisms it can ...

BACKGROUND The common carp is an important aquaculture species that is widely distributed across the world. During the long history of carp domestication, numerous carp strains with diverse skin colors have been established. Skin color is used as a visual criterion to determine the market value of carp. However, the genetic basis of common carp skin color has not been extensively studied. MET...