Despite recognition of acute respiratory distress syndrome in both falciparum and vivax malaria, disease-related changes in pulmonary function have not been defined, and underlying mechanisms are not well understood. Respiratory symptoms, pulmonary function, pulmonary phagocytic cell activity, and longitudinal changes were examined in 26 adults with uncomplicated falciparum, vivax, and ovale ma...

Plasmodium falciparum malaria poses an increasing risk to travellers to West Africa. The development of chloroquine resistant in West Africa has further compounded the risk. Two cases of falciparum malaria from Sierra Leone are presented. One represents the classic missed case and the other a probable case of chloroquine resistant (RI vide infra) falciparum malaria. These cases highlight the da...

BACKGROUND High seroprevalence of parvovirus B19 (B19V) coinfection with Plasmodium falciparum has been previously reported. However, the impact of B19V-infection on the clinical course of malaria is still elusive. In this study, we investigated the prevalence and clinical significance of B19V co-infection in Gabonese children with malaria. METHODS B19V prevalence was analyzed in serum sample...

BACKGROUND & OBJECTIVE The present study was conducted on the prevalence of malaria as co-infection amongst 'asymptomatic HIV' and 'symptomatic HIV' subjects to see if such prevalence deviated from that commonly reported in apparently health individuals in same locality. METHODS A prospective study that involved 196 participants grouped according to their HIV status as: 'asymptomatic HIV sero...

BACKGROUND Few data exist concerning pathogenesis of severe malaria in areas of unstable malaria transmission. OBJECTIVES The study was conducted in Senga hospital, central Sudan, which is characterized by unstable malaria transmission to investigate the cytokine profiles in children with severe Plasmodium falciparum malaria. METHODS Enzyme-linked immunosorbent assay was used to measure the...

Background: Cerebral malaria (CM) is one of the major causes of death in African populations infected with Plasmodium falciparum. Only 1% of infected subjects develop CM. The reasons for these differences are not fully understood, but it is likely that the host humoral response against blood-stage antigens plays a role in protection from malaria, although the precise targets and mechanisms medi...

Malaria is a potentially life-threatening disease with approximately half of the world’s population at risk. Young children and pregnant women are hit hardest by disease. B cells antibodies part an adaptive immune response protecting individuals continuously exposed to parasite. An infection Plasmodium falciparum can cause dysregulation cell homeostasis, while known be key in controlling sympto...

HIV infected individuals in malaria endemic areas experience more frequent and severe malaria episodes compared to non HIV infected. This clinical observation has been linked to a deficiency in antibody responses to Plasmodium falciparum antigens; however, prior studies have only focused on the antibody response to <0.5% of P. falciparum proteins. To obtain a broader and less-biased view of the...

The combination of anemia in malarial infestations ranges from nutritional deficiency to marrow suppression. An immune hemolytic anemia in Plasmodium falciparum malaria is also a part of this wide-ranging spectrum. But the co-existence of cold agglutinins in a Plasmodium falciparum malaria has only sporadically been reported in literature. We present a case of a patient with falciparum malaria ...

BACKGROUND Mortality from severe pediatric falciparum malaria appears low in Oceania but Plasmodium vivax is increasingly recognized as a cause of complications and death. The features and prognosis of mixed Plasmodium species infections are poorly characterized. Detailed prospective studies that include accurate malaria diagnosis and detection of co-morbidities are lacking. METHODS AND FINDI...