نتایج جستجو برای: factor viia

تعداد نتایج: 844421  

2014
Ke Ke Jian Yuan James H. Morrissey

Blood clotting is initiated by the two-subunit enzyme consisting of the plasma protease, factor VIIa (the catalytic subunit), bound to the integral membrane protein, tissue factor (the regulatory subunit). Molecular dynamics simulations have predicted that certain residues in the tissue factor ectodomain interact with phosphatidylserine headgroups to ensure optimal positioning of the tissue fac...

Journal: :The Journal of clinical investigation 1993
H ten Cate K A Bauer M Levi T S Edgington R D Sublett S Barzegar B L Kass R D Rosenberg

The human coagulation system continuously generates very small quantities of Factor Xa and thrombin. Current evidence suggests that basal level activation of the hemostatic mechanism occurs via Factor VIIa-dependent activation of Factor X, but direct proof has not been available for the participation of tissue factor in this pathway. To examine this issue, we infused relatively high concentrati...

Journal: :The American surgeon 2012
Carlos V R Brown Lauren Sowery Eardie Curry Alex B Valadka Cynthia S Glover Kim Grabarkewitz Terry Green Steve Hail John Admire

Timely correction of coagulopathy in patients with traumatic brain injury (TBI) improves mortality. Recombinant, activated factor VII (VIIa) has been identified as an effective method to correct coagulopathy in patients with TBI. We performed a retrospective study (January 1, 2008-December 31, 2009) of all patients with TBI and coagulopathy (international normalized ratio (INR) > 1.5) transfer...

Journal: :Journal of Thrombosis and Haemostasis 2004

Journal: :Molecular medicine reports 2014
Ying Wu Jing Wang Hong Zhou Xiaoyan Yu Lichao Hu Fanlu Meng Shuanghong Jiang

Tissue factor (TF)/VIIa/protease‑activated receptor 2 (PAR2) has been shown to trigger the ERK1/2 signaling pathway. This was shown to be closely associated with the proliferation and migration of SW620 colon cancer cells; however, the detailed mechanisms remain unclear. The aim of the present study was to elucidate the effects of calcium signaling on the proliferation and migration of SW620 ce...

Journal: :The Journal of biological chemistry 1994
J H Lawson M Kalafatis S Stram K G Mann

The activation of prothrombin, factor V, factor VIII, factor IX, and factor X by the tissue factor-factor VIIa complex, in vitro, in a system in which each precursor protein was present at plasma concentration, was evaluated using a combination of activity assays, immunoblots, active-site blots, and autoradiography. The thrombin generation curves observed were distinctly nonlinear and typically...

Journal: :Journal of thrombosis and haemostasis : JTH 2004
M S Goel S L Diamond

BACKGROUND Tissue factor (TF) and/or active factor (F)VIIa may be stored inside resting platelets. OBJECTIVES The objective of this study was to examine if platelets, following activation of GPVI, could support tenase and prothrombinase activity without any exogenously added tissue factor. METHODS Thrombin (IIa) formation on gel-filtered platelets with added factors or the clotting of plate...

Journal: :The Journal of biological chemistry 2000
H H Versteeg I Hoedemaeker S H Diks J C Stam M Spaargaren P M van Bergen En Henegouwen S J van Deventer M P Peppelenbosch

Tissue factor (TF), apart from activating the extrinsic pathway of the blood coagulation, is a principal regulator of embryonic angiogenesis and oncogenic neoangiogenesis, but also influences inflammation, leukocyte diapedesis and tumor progression. The intracellular domain of TF lacks homology to other classes of receptors and hence the signaling mechanism is poorly understood. Here we demonst...

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