A patient presenting an unusual clinical picture was recently admitted to the New Haven Hospital. She showed definite objective evidence of involvement of the central nervous system, but other obscure signs present made an accurate diagnosis difficult. At necropsy a most unexpected lesion was found involving the base of the brain, the nerve roots, and the spinal cord. The case is of particular ...

Four patients are described in whom a follicular carcinoma developed following thyroidectomy for a benign follicular neoplasm. It is possible that the initial thyroid neoplasm was a well- differentiated follicular carcinoma which was microscopically indistinguishable from a benign adenoma. Realizing this pathologic pitfall in thyroid diagnosis, the need for meticulous examination of the pa...

Objective We describe a case of bilateral sequential optic neuropathies with pachymeningitis and aortitis, findings that raised suspicion Erdheim-Chester disease versus IgG-4 related disease. Background (ECD) is rare histiocytic neoplasm characterized by tissue infiltration foamy histiocytes, chronic, uncontrolled inflammation. IgG4-related (IgG4-RD) an insidiously progressive immune-mediated f...

Within a cohort of 1,915 consecutive patients with myeloproliferative neoplasm followed for a median time of 5.2 years (range 0-33.3), we investigated the occurrence of lymphoid neoplasm with the aim of defining this risk and to investigate the role of genetic predisposing factors. We identified 22 patients with myeloproliferative neoplasm who developed lymphoid neoplasm over their lifetime. We...

Ovarian sex cord-stromal tumors are relatively infrequent neoplasms that account for approximately 8% of all primary ovarian neoplasm. Sex cord-stromal tumors of the ovary include granulosa cell tumors, fibrothecomas, Sertoli-Leydigcell tumors, steroid cell tumors, and sclerosing stromal tumors (SST). Sclerosing stromal tumors account for 2% to 6% of ovarian stromal tumors. Despite the rarity o...

Purpose. To analyze and describe corneal and conjunctival tumor thickness and internal characteristics and extension in depth and size and shape measured by two noninvasive techniques, anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM). Design. Systematic review. Methods. This systematic review is based on a comprehensive search of 4 databases (Medline, Em...

purpose: to report the development of cataract after corneal damage by dungle beetle prongs. case report: a 28 year-old man, resident of the village chah setareh, sabzevar, presented complaining of trauma to the right eye with the dangle beetle while motorcycling. slit lamp examination revealed six corneal perforations, hyphema (50% of anterior chamber) percent, iris sphincter rupture, and rupt...

A 6-week-old girl was referred for management of a large left orbital and periorbital capillary hemangioma (Figure 1, Figure 2, Figure 3 and Figure 4; available at http://aaojournal.org). The neoplasm had been present since birth and getting progressively larger with resultant occlusive, anisometropic, and strabismic amblyopia of the left eye. She had received 1 intralesional steroid injection ...

computers are used everywhere from home to work these days, thus the effects on the visual system will be more noticeable every day. problems associated with computer usage are generally known as the computer vision syndrome (cvs).these problems include eye fatigue, irritation ,redness , blurred vision and dry eye. all of these problems have adverse effects on individuals in the long term and r...