The present work aimed to investigate the impact of critical material attributes on design space production lysozyme pellets with suitable biological and physical properties for subsequent coating process. effect two brands both conformation stabilizing mannitol behavior composition in an extrusion/spheronization process was studied, while experiments were designed according 2 3 factorial desig...

*To whom all correspondence should be addressed. uring the past few decades, various types of oral controlled-release (CR) formulations have been developed to improve the clinical efficacy of drugs having short half lives as well as to increase patient compliance (1, 2). These formulations are designed to deliver drugs at a predetermined rate over a wide range of conditions and durations of the...

Objective: The objective of the present work was to optimize a rectal suppository containing mucoadhesive pellets Mesalamine achieve local yet sustained release for once-a-day administration therapy Inflammatory Bowel Disease. Methods: Thus, involves forming mesalamine by extrusion spheronization, which were then loaded into be administered rectally. evaluated mucoadhesion strength, swelling po...