We describe N-[(2S)-2-(mercaptomethyl)-3-methylbutanoyl]-4-(1H-pyrazol-1-yl)-L-phenylalanine (GW796406), a vasopeptidase inhibitor (VPI) that possessed approximately 3-fold selectivity for neutral endopeptidase 24.11 (NEP) versus angiotensin-converting enzyme (ACE) in in vitro assays using rat and human enzymes. In the same assays, omapatrilat, the most extensively studied VPI, displayed approx...

Extravasation is defined as the leakage of fluid from a blood vessel into surrounding area at injection site. These accidents occur during for diagnostic or therapeutic purposes, carried out through peripheral central venous lines (Chemotherapy, metabolites, contrast agent radiographic examination). They can be cause skin necrosis able to progress significant functional, cosmetic, and psycholog...