We report on a method for three-dimensional cultivation of cells in a microstructured asymmetric environment. In the system an asymmetric environment is created by using diffusion through a gel of extra cellular matrix proteins surrounded by microfluidic flow channels. Individual cells embedded in the gel react on the concentration gradient. The system has been evaluated both for diffusion prop...

Background & Aims: Atherosclerosis is a major cause of morbidity and mortality. Adiponectin reducesthe risk of heart disease, and matrix metalloproteinase-9 (MMP-9) is involved in the formation and development of atherosclerotic plaque. The aim of this study was the investigation of the effect of adiponectin on MMP-9 gene expression. It seems this hormone can reduce the risk of atherosclerosis ...

Overweight leads to arthrosis through various factors: -1) the level, frequency, and type of constraints induced by overweight have a direct mechanical effect on the cartilage, meniscus, and ligaments -2) mechanical receptors of the cellular membrane of chondrocytes allow the chondrocyte to evaluate the articular pressure. This mechanical signal induces chemical liberation of mediators and enzy...