It is unknown whether acute response to ambulatory oxygen (O2) predicts longer term improvement in health-related quality of life (HRQL) in chronic obstructive pulmonary disease (COPD) patients. The aims of this study were 1) to assess the short-term clinical impact, as determined by HRQL, of ambulatory O2 in a 12-week, double-blind, randomised crossover study of O2 (versus cylinder compressed ...

INTRODUCTION Pulmonary siderosis secondary to the inhalation of iron compounds is a rare condition which, despite striking radiological and histopathological features, has not traditionally been associated with symptoms or functional impairment. Although not the first of its kind, we present an unusual case of pulmonary siderosis with symptomatic respiratory disease, most likely secondary to as...

Sixteen working welders with more than seven years' exposure and a chest radiograph suggestive of siderosis and I3 healthy unexposed men were studied. Each subject had a comprehensive medical and work history, physical examination, standard chest film, and pulmonary function investigation (lung volumes, ventilatory capacities, pulmonary compliance in static and dynamic conditions, specific comp...

The Assessment of Military Multitasking Performance (AMMP) is a battery of functional dual-tasks and multitasks based on military activities that target known sensorimotor, cognitive, and exertional vulnerabilities after concussion/mild traumatic brain injury (mTBI). The AMMP was developed to help address known limitations in post concussive return to duty assessment and decision making. Once v...

BACKGROUND Lymphangioleiomyomatosis (LAM) is a progressive lung disease that impairs health-related quality of life (HRQL). OBJECTIVE To develop and conduct initial testing of ATAQ-LAM (A Tool to Assess Quality of Life in LAM). METHODS A pilot version of the questionnaire was administered to respondents with LAM. We used a deletion algorithm to retain items and then applied multi-trait scal...

A 13-yr-old Congolese female presented in early spring with a 6-month history of productive cough, progressive exertional dyspnoea and weight loss of 4.5 kg. 2 weeks prior to presentation she had developed high fevers and increasing lethargy. She had immigrated to the UK at the age of 2 yrs. She had not been overseas since and there was no history of contact with anyone with tuberculosis (TB). ...

In short, the diagnosis ofDPB is usually difficult inmanypatients due to the non-specific clinical and radiological characteristics, in addition to the fact that it is not suspected due to its infrequency in Western countries. Nevertheless, it should be kept in mind when evaluating patients without a history of smokingwho present with exertional dyspnea, chronic productive cough, and tree-in-bu...

A 68-year-old male, presented with exertional dyspnoea and chest pain in his anterior chest wall for 3 months. He had no previous history of cardiac disease. Clinical examination failed to show anything significant. Chest X-ray showed a mass superimposed over the upper cardiac silhouette. He was further evaluated by chest CT, which showed a cystic mass in the anterior mediastinum measuring 9 x ...

Human pregnancy is characterized by significant increases in ventilatory drive both at rest and during exercise. The increased ventilation and attendant hypocapnia of pregnancy has been attributed primarily to the stimulatory effects of female sex hormones (progesterone and estrogen) on central and peripheral chemoreflex drives to breathe. However, recent research from our laboratory suggests t...