It is generally agreed that, above the level of the 30 nm fibre, eukaryotic chromatin is constrained into loops, but there is disagreement about the nature of the substructure that serves to anchor loops and the DNA sequences that act as the attachment sites. This problem may stem from the very different methods that all purport to separate loop and attached DNAs. We have tested ideas about how...

BACKGROUND Many studies have examined the efficacy of psychotherapy for major depressive disorder (MDD) but publication bias against null results may exist in this literature. However, to date, the presence of an excess of significant findings in this literature has not been explicitly tested. METHOD We used a database of 1344 articles on the psychological treatment of depression, identified ...

protein tyrosine phosphatases (ptpases) regulate the tyrosine phosphorylation of target proteins in volved in several biological activities including cell proliferation and transformation. protein tyrosine phosphatase e (ptpe) contains duplicated ptpase-like domains and a short extracellular region. us ing the fluorescence in situ hybridization method, the gene encoding ptpe (locus symbol ptpre...

The aim of this study was to identify potential biomarkers for radiosensitivity using the relationship between cell killing and the yield of excess chromatin fragments detected with the premature chromosome condensation (PCC) technique. This method was applied to primary cultured cells obtained from biopsies from patients. Six primary culture biopsies were obtained from 6 patients with carcinom...

Protein tyrosine phosphatases (PTPases) regulate the tyrosine phosphorylation of target proteins in‌volved in several biological activities including cell proliferation and transformation. Protein tyrosine phosphatase E (PTPE) contains duplicated PTPase-like domains and a short extracellular region. Us‌ing the fluorescence in situ hybridization method, the gene encoding PTPE (locus symbol Ptpre...

The meiotic chromosomes of 3 bulls carrying the 1/29 Robertsonian translocation have been studied. The abnormal chromosome was found in the spermatogonial mitotic divisions of the 3 animals studied. At the diacinesis stage, the trivalent presented several types of association. Chromosome counting of metaphases II showed the presence of 30.2 p. 100 of unbalanced karyotype cells due to excess or ...

 Abstract Background: To produce a reliable probe suitable for aneuploidy detection of chromosome 13 on uncultured lymphocytes and amniocytes by fluorescence in situ hybridization (FISH), we used a contig of three overlapping cosmids mapped to 13q12.3. Methods: The cosmid DNA carrying the expected sequences of human chromosome 13 was isolated from host cells and labelled with biotin-11-dUTP. Th...