نتایج جستجو برای: eudragit rl100
تعداد نتایج: 830 فیلتر نتایج به سال:
The objective of this work was to study the dissolution process from piroxicam pellets, coated with Eudragit RS 30 D by fluidized bed, in order to achieve an enteric release of the drug. The coating product contains a methacrylic copolymer which is insoluble, but permeable. The drug-loaded pellets were prepared by extrusionspheronization using microcrystalline cellulose (Avicel PH 101) as a sph...
The vaginal route of administration is an alternative for several treatments for either local or systemic pharmacological effects. However, the permanence of a drug in this route represents a challenge for formulation development that can be overcome by using nanoencapsulation and chitosan gel. Thus, this work aimed to evaluate the performance of chitosan hydrogels containing cationic and anion...
BACKGROUND Particulate systems have received increasing attention for oral delivery of biomolecules. The objective of the present study was to prepare submicron particulate formulations of papain for pH-dependent site-specific release using pH-sensitive polymers. METHODS Enteric submicron particle formulations of papain were prepared by w/o/w emulsion solvent evaporation using hydroxypropyl m...
زمینه و هدف: اشکال مخاط چسب، از سیستم های دارورسانی جدید هستند که بصورت قرص و فیلم موجودند. فیلم مخاط چسب دهانی زمان توقف دارو را طولانی می کند و یک شیب بالای غلظتی برای نفوذ ارائه می دهد که منجر به بهبود جذب دارو می شود. هدف از این مطالعه تهیه سیستم تحویل منطقه ای داروی ایبوپروفن به منظور تسکین درد و التهاب خفیف تا متوسط دهانی از طریق تهیه ی فرمولاسیون مخاط چسب دهان بود. روش بررسی: در این مط...
The aim of this study was to develop a dry powder coating process for chlorpheniramine maleate (CPM) tablets using Eudragit L 100-55 as the delayed release polymer. Powder coating, a water and organic solvent-free process, was investigated as a method to prevent the migration of an ionizable, highly water soluble model drug into the polymeric film during the coating process. Eudragit L 100-55 w...
BACKGROUND AND THE PURPOSE OF THE STUDY Mechanical properties of films prepared from aqueous dispersion and organic solutions of Eudragit RL were assessed and the effects of plasticizer type, concentration and curing were examined. METHODS Films were prepared from aqueous dispersion and solutions of Eudragit RL (isopropy alcohol-water 9:1) containing 0, 10 or 20% (based on polymer weight) of ...
Eudragit-E was originally developed as a non-adhesive liquid embolic material in the late 1990s and is a copolymer of methyl and butyl methacrylate and dimethylaminoethyl methacrylate that is dissolved in ethanol and iopamidol. This material has been used for endovascular embolization of brain arteriovenous malformations (AVMs) for some time but is currently not widely used. Because safety and ...
In this study, amorphous solid dispersions containing dutasteride and various excipients, manufactured by spray-drying processes, were characterized to determine the effects on their ability to form supersaturated solutions and to identify the effects of supersaturation on increasing the bioavailability of dutasteride. The excipients included Eudragit E, hydroxypropyl-β-cyclodextrin (HP-β-CD), ...
OBJECTIVES The aim of this study was to investigate the possibility of production of ibuprofen pellets with high amount of rate retarding polymer by aid of PEG400 as plasticizer. MATERIALS AND METHODS Polyethylene glycol (PEG400) in concentrations of 1, 3 or 5% w/w with respect to Eudragit RL was used in production of pellets containing 60% ibuprofen and 40% excipient (2% polyvinylpyrrolidone...
Partially purified α-galactosidase from Bacillus sp. LX-1 was non-covalently immobilized on a reversibly soluble-insoluble polymer, Eudragit L-100, and an immobilization efficiency of 0.93 was obtained. The optimum pH of the free and immobilized enzyme was 6.5 to 7.0 and 7.0, respectively, while there was no change in optimum temperature between the free and immobilized α-galactosidase. The imm...
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