BACKGROUND In this retrospective comparative study, we aimed to compare the effectiveness of fentanyl, midazolam, and a combination of fentanyl and midazolam to prevent etomidate-induced myoclonus. MATERIAL AND METHODS This study was performed based on anesthesia records. Depending on the drugs that would be given before the induction of anesthesia with etomidate, the patients were separated ...

37. Davies B, Morris T: Physiological parameters in laboratory animals and humans. Pharm Res 1993; 10:1093–5 38. Fraser R, Watt i, gray Ce, ledingham iM, lever AF: the effect of etomidate on adrenocortical function in dogs before and during hemorrhagic shock. endocrinology 1984; 115:2266–70 39. Kruse-elliott Kt, swanson CR, Aucoin DP: effects of etomidate on adrenocortical function in canine su...

Etomidate is a hypnotic drug used as an intravenous anaesthetic induction agent. causes myoclonic movements in 50-80% patients after which makes it less desirable for induction. Aim: Present study was to determine the effect of priming preventing injection with etomidate adult undergoing cardiac surgery. Materials and Methods: 108 ASA grade III scheduled elective surgery were allocated randomly...

INTRODUCTION Etomidate blocks adrenocortical synthesis when it is administered intravenously as a continuous infusion or a single bolus. The influence of etomidate administration on the incidence of relative adrenal insufficiency in patients with septic shock has not been formally investigated. The objective of this study was to determine the incidence of relative adrenal insufficiency in patie...

BACKGROUND Concerns over adrenal suppression caused by a single dose of etomidate for intubation led to limiting its use in trauma patients in 2006. OBJECTIVE The purpose of this study was to compare mortality, hypotension, and intensive care unit (ICU) and hospital length of stay (LOS) for trauma patients requiring intubation during periods of liberal vs. limited etomidate use. METHODS A r...

BACKGROUND We aimed to investigate the effect of electroacupuncture at Zusanli (ST36) and Sanyinjiao (SP6) on adrenocortical function in patients with etomidate anesthesia. MATERIAL AND METHODS We randomly divided 80 patients who underwent elective surgery into 4 groups: group etomidate (ETO), group etomidate + electroacupuncture (ETO+EA), group etomidate + sham acupuncture (ETO+SEA), and gro...

Etomidate is a commonly used anesthetic agent often utilized to induce anesthesia as it has a short half-life and allows for central nervous system depression without causing major cardiovascular disturbances, making it one of the preferred medications for trauma and hemodynamically unstable patients. Thus, etomidate is commonly found during a postmortem drug screen conducted for medicolegal re...

OBJECTIVES The objective of this study was to compare first-pass intubation success between patients who received etomidate versus ketamine for rapid sequence intubation (RSI) in the emergency department (ED). METHODS This was a retrospective analysis of prospectively collected data recorded in a quality improvement database between July 1, 2007, and December 31, 2012. The study was conducted...

Etomidate is a widely used IV anesthetic, but little is known about its analgesic properties, in particular, its effects on spinal cord neuronal responses to noxious stimuli. We hypothesized that etomidate would depress lumbar neuronal responses to noxious heat. Rats (n = 15) were anesthetized with isoflurane (1.2%) and laminectomy was performed to record single unit activity. Lumbar neuronal r...

We have investigated the effects of etomidate 4.4 mumol litre-1, 1.0 mg litre-1 and 27.4 mumol litre-1, 6.25 mg litre-1 on whole-cell and single L-type calcium channel currents in myocytes from guineapig ventricles. For whole-cell recordings, the cells were voltage-clamped and step depolarizations were applied from holding potential of -40 mV to various potentials to elicit L-type calcium curre...