The streptomycin molecule contains a number of functional groups which may serve as bases for chemical assay. The Sakaguchi reaction has been used to test for the guanido groups of the molecule (l), and a reaction given by the N-methyl-L-glucosamine moiety (2) of streptomycin has been reported (3). Furthermore, the molecule has a free or potentially free carbonyl group (4) and marked reducing p...

The simplicity and reproducibility which characterize the conversion of streptomycin to malt01 (1) by heating in dilute alkali have made this reaction the basis of a frequently used analytical method for streptomycin (2). When used in these laboratories as a method of assaying streptomycin preparations, however, the malt01 reaction consistently gave lower yields per unit of potency with pure st...

A 3-hydro-4-pyridinone compound derived from maltol and dopamine has been prepared using a microwave reactor. The molecular structure of the protonated product was confirmed by single crystal X-ray diffraction. Crystals were obtained from a saturated solution of methanol and belong to the triclinic space group P-1 with unit cell parameters a = 8.3801(11) Å; b = 9.2583(12) Å; c = 11.5671(15) Å; ...

Aims To analyse content and emission data submitted by manufacturers for nicotine-containing vaping products in the United Kingdom (UK) accordance with European Union Tobacco Products Directive. Design Analysis of ingredient reported all e-liquid-containing e-cigarettes, cartridges or refill containers notified to Medicines Healthcare Regulatory Agency (MHRA) from November 2016 October 2017. Se...

The effect of food components on degradation of DNA by DNase I (EC 3.1.21.1) was monitored by electrotransformation of Escherichia coil, making it possible to determine the number of plasmid molecules capable of giving rise to transformed cells. The transformation frequency increased linearly with the plasmid number within the range of 2 x 10(6) to 2 x 10(10). DNA degradation was reduced by one...

Iron overload is a clinical problem which can be prevented by using iron chelating agents. An alternative method of relieving iron overload is to reduce iron absorption from the intestine by administering specific iron chelating agents, which can bind iron to form nonabsorbable complexes. Based on this strategy, a series of polymeric ligands containing the chelating moiety 3-hydroxypyridin-4-on...

Introduction: Due to the cell labeling potentials of various metal-maltol complexes, the idea of developing a possible cell labeling imaging agent using single photon emission computed chromatography (SPECT) with [In]-maltolate complex has been investigated. Methods: [In] labeled 3-hydroxy-2-methyl-4H-pyran-4-onate ([In]-maltolate) was prepared using freshly prepared [In]InCl3 and 3-hydroxy-2-m...