A 2.7-kilobase DNA fragment carrying the entire exotoxin A (ETA) structural gene was divided into three nonoverlapping probes. Two probes covering the ETA structural gene were used in colony hybridization experiments to determine whether sequences homologous to the ETA gene could be detected in genera other than Pseudomonas or in Pseudomonas species other than Pseudomonas aeruginosa. The majori...

The eta-subunit of the TCR is derived from an alternative splice product of the TCR-zeta gene. The eta-subunit has been extensively characterized in murine T cells, where up to 10% of TCR bear zeta-eta heterodimers rather than zeta-homodimers. In contrast to the significant levels of eta found in murine T cells, in human PBL an eta-like region is expressed spliced to upstream exons of the zeta-...

In vitro and in vivo techniques were developed with genetically modified mice to determine whether endothelin-1 (ET-1) functions as an O2 mediator in closure of the ductus arteriosus (DA) at birth. Wild-type CD-1 and 129/SvEv mice with ETA receptor -/-, +/-, and +/+ genotypes were used. Isolated DA from term ETA +/+ fetuses contracted to O2 (5-95%) and a thromboxane A2 analog (ONO-11113, 0.1 μM...

The effects of endothelin (ET) receptor blockade on energy utilization in heart failure (HF) are unknown. We administered ET type A (ETA), ET type B (ETB), and ETA/ETB antagonists to isolated hearts from Dahl salt-sensitive (DS) rats with HF and controls. Contractile efficiency was assessed as slope-1 of myocardial O consumption (VO2)-pressure-volume area relation. In HF, ETA and ETA/ETB but no...

2 Local symplectic, complex and Kähler geometry: a quick review 10 2.1 Quotients . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 2.2 Symplectic manifolds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 2.3 Symplectic quotients . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 2.4 Complex manifolds . . . . . . . . . . . . . . ....

Endothelin is a vasoconstricting peptide that plays a key role in vascular homeostasis, exerting its biologic effects via two receptors, the endothelin receptor A (ETA) and endothelin receptor B (ETB). Activation of ETA and ETB has opposing actions, in which hyperactive ETA is generally vasoconstrictive and pathologic. Selective ETA blockade has been shown to be beneficial in renal injuries suc...

This study was designed to explore the placebo-controlled effects of risperidone on cognitive-motor processes, dyskinetic movements, and behavior in children receiving maintenance risperidone therapy. Sixteen children aged 4-14 years with disruptive behavior were randomly assigned to drug order in a crossover study of risperidone and placebo for 2 weeks each. Dependent measures included tests o...

It has been argued that the notion of substitution in the λ-calculus needs to be made explicit and many calculi have been developed in which the computational steps of the substitution operation involved in β-contractions have been atomised. In contrast to the great variety of developments for making explicit formalisations of the Beta rule, less work has been done for giving explicit definitio...

Methods Among patients with JIA treated with ETA from 2000 (n = 46), we identified patients in remission defined by a sustained good clinical response according to physicians of our departments for at least 1,5 years and discontinued ETA. The disease course was evaluated using physician and parent/patients VAS for disease activity, active joints, joints with LOM, CHAQ, ESR, CRP. A bivariate ana...