Little is known about the combined effect of environmental factors and contaminants on commercially important marine species, whether this differs by sex. In study, blue mussels were exposed for seven days to both single stressors (i.e., +3 °C elevated temperature two environmentally relevant concentrations plastic softener DEHP, 0.5 50 μg/l) in a factorial design. Males observed be more sensit...

background and objective: breast cancer is the commonest cancer of indian women. estrogen and progesterone expression is seen in benign breast lesions and in breast carcinoma associated with good prognostic parameters and it correlates well with response to hormone therapy. although a lot of studies have been conducted in the past on hormone receptor expression in breast cancer and few have cor...

the hippocampal system plays an important role in memory function. neurohormones like androgens and estrogens that syntheses in hippocampus have an important role in learning and memory. many biological effects of estrogens in the brain via estrogenic receptors (ers) are investigated. the current research has conducted to assess the effect of estrogenic receptors on spatial discrimination in ra...

alzheimer’s disease (ad) is a disorder with multiple pathophysiological causes, destructive outcomes, and no available definitive cure. pelargonidin (pel), an anthocyanin derivative, is an estrogen receptor agonist with little estrogen side effects. this study was designed to assess pel memory enhancing effects on the a rat amyloid beta 25-35 (aβ) intrahippocampal microinjections model of ad in...

To gain insight into the in vivo role of estrogen, we isolated estrogen receptor-positive cells fromnormal human breast tissue using a recombinant adenovirus that expresses green fluorescence protein in response to estrogen. We compared the global gene expression profile of these estrogen receptor-positive cells with that of various normal and cancerous mammary epithelial cells and identified s...

objective(s): estrogen receptor-alpha (erα) mediates estrogen action in regulation of different levels of the hypothalamic-pituitary-testis axis. it has a key role in spermatogenesis. estrogen receptor alpha knock-out (er koα) male mice were infertile and severe impairment in spermatogenesis and seminiferous tubules was observed. recently, it has been reported that microrna (mirna) mir-100 and ...