The proline hydroxylase domain-containing enzymes (PHD) act as cellular oxygen sensors and initiate a hypoxic signal cascade to induce a range of cellular responses to hypoxia especially in the aspect of energy and metabolic homeostasis regulation. AMP-activated protein kinase (AMPK) is recognized as a major energetic sensor and regulator of cardiac metabolism. However, the effect of PHD signal...

BACKGROUND Many systems for routine public health surveillance rely on centralized collection of potentially identifiable, individual, identifiable personal health information (PHI) records. Although individual, identifiable patient records are essential for conditions for which there is mandated reporting, such as tuberculosis or sexually transmitted diseases, they are not routinely required f...

We study the obstacle problem for fully nonlinear elliptic operators with an anisotropic degeneracy on gradient: $$ \left{\begin{array}{rll} \min\left{f-|Du|^\gamma F(D^2u),u-\phi\right} &= 0 & \textrm{ in } \Omega,\ u = g \partial \Omega, \end{array}\right. some parameter $\gamma\geq 0$, uniformly operator $F$, bounded source term $f$, and suitably smooth $\phi$ boundary datum $g$. obtain exis...

To any graph G we can associate a simplicial complex ∆(G) whose simplices are the complete subgraphs of G, and thus we say that G is contractible whenever ∆(G) is so. We study the relationship between contractibility and K-nullity of G, where G is called K-null if some iterated clique graph of G is trivial. We show that there are contractible graphs which are not K-null, and that any graph whos...

The conformational behaviour of delta Ala has been investigated by quantum mechanical method PCILO in the model dipeptide Ac-delta Ala-NHMe and in the model tripeptides Ac-X-delta Ala-NHMe with X = Gly, Ala, Val, Leu, Abu and Phe and is found to be quite different. The computational results suggest that in the model tripeptides the most stable conformation corresponds to phi 1 = -30 degrees, ps...

Control of cytoplasmic pH (pHi) by a Na+/H+ antiport appears a general property of most eukaryotic cells. In human platelets activation of the Na+/H+ exchanger enhances Ca2+ mobilization and aggregation induced by low concentrations of thrombin (Siffert, W., and Akkerman, J. W. N. (1987) Nature 325, 456-458). Several observations indicate that the exchanger is regulated by protein kinase C. (i)...

Many essential cellular processes are affected by transmembrane H(+) gradients and intracellular pH (pHi). The research of such metabolic events calls for a non-invasive method to monitor pHi within individual subcellular compartments. We present a novel confocal microscopy approach for the determination of organellar pHi in living cells expressing pH-dependent ratiometric fluorescent proteins....

let $mathcal{a}$ and $mathcal{b}$ be two $c^{*}$-algebras such that $mathcal{b}$ is prime. in this paper, we investigate the additivity of maps $phi$ from $mathcal{a}$ onto $mathcal{b}$ that are bijective, unital and satisfy $phi(ap+eta pa^{*})=phi(a)phi(p)+eta phi(p)phi(a)^{*},$ for all $ainmathcal{a}$ and $pin{p_{1},i_{mathcal{a}}-p_{1}}$ where $p_{1}$ is a nontrivial projection in $mathcal{a...

Let $mathcal{A}$ and $mathcal{B}$ be two $C^{*}$-algebras such that $mathcal{B}$ is prime. In this paper, we investigate the additivity of maps $Phi$ from $mathcal{A}$ onto $mathcal{B}$ that are bijective, unital and satisfy $Phi(AP+eta PA^{*})=Phi(A)Phi(P)+eta Phi(P)Phi(A)^{*},$ for all $Ainmathcal{A}$ and $Pin{P_{1},I_{mathcal{A}}-P_{1}}$ where $P_{1}$ is a nontrivial projection in $mathcal{A...