Nucleic acid secondary structure plays an important role in nucleic acid-nucleic acid recognition/hybridization processes, and is also a vital consideration in DNA nanotechnology. Although the influence of stable secondary structures on hybridization kinetics has been characterized, unstable secondary structures, which show positive ΔG° with self-folding, can also form, and their effects have n...

Competitive hybridization, at the surface and in the bulk, lowers the sensitivity of DNA chips. Competitive surface hybridization occurs when different targets can hybridize with the same probe. Competitive bulk hybridization takes place when the targets can hybridize with free complementary chains in the solution. The effects of competitive hybridization on the thermodynamically attainable per...

Other work has shown that adaptive learning can be highly successful in developing programs which are able to play games at a level similar to human players and, in some cases, exceed the ability of a vast majority of human players. This study uses poker to investigate how adaptation can be used in games of imperfect information. An internal learning value is manipulated which allows a poker pl...

Players of complex board games like backgammon, chess and go, were always wondering what the best opening moves for their favourite game are. In the last decade, computer analysis has offered more insight to many opening variations. This is especially true for backgammon, where computer rollouts have radically changed the way human experts play the opening. In this paper we use Palamedes, the w...

The resilience of populations to rapid environmental degradation is a major concern for biodiversity conservation. When environments deteriorate to lethal levels, species must evolve to adapt to the new conditions to avoid extinction. Here, we test the hypothesis that evolutionary rescue may be enabled by hybridization, because hybridization increases genetic variability. Using experimental evo...

Translocations involving chromosome 21q22 are frequently observed in hematologic malignancies including acute myeloid leukemia (AML), most of which have been known to be involved in malignant transformation through transcriptional dysregulation of Runt-related transcription factor 1 (RUNX1) target genes. Nineteen RUNX1 translocational partner genes, at least, have been identified, but not Homeo...

northern regions of khuzestan province are suitable areas for soybean cultivation. hybridization blocks and soybean segregating generations were established in safiabad agricultural research center during 1990-1997 to produce new soybean lines which would have a high seed yield and high adaptability to the region. line l.14 selected from segregating generations of a hybridization between cultiv...

Climate change is profoundly affecting the evolutionary trajectory of individual species and ecological communities, in part through the creation of novel species assemblages. How climate change will influence competitive interactions has been an active area of research. Far less attention, however, has been given to altered reproductive interactions. Yet, reproductive interactions between form...

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