Aim: To compare the safety and efficacy of lidocaine and esmolol, in modifying the hemodynamic response to laryngoscopy and intubation. Design: Randomized, placebo-controlled, double-blind study was carried out in Fauji Foundation hospital Lahore from 1 st June 2012 to 31 st August 2012,after taking written informed consent from patients and permission from medical and ethical committee of hosp...

BACKGROUND Laryngoscopy and intubation increases blood pressure and heart rate. OBJECTIVE The study aims to investigate the effect and safety of gabapentin, esmolol or their combination on the haemodynamic response to laryngoscopy and intubation. METHODS A total of 72 patients undergoing elective surgery were randomly allocated to one of the four groups. First study drug was administered or...

INTRODUCTION Esmolol may efficiently reduce heart rate (HR) and decrease mortality during septic shock. An improvement of microcirculation dissociated from its macrocirculatory effect may a role. The present study investigated the effect of esmolol on gut and sublingual microcirculation in a resuscitated piglet model of septic shock. METHODS Fourteen piglets, anesthetized and mechanically ven...

The present study reports a case of electrical storm occurring in a 43-year-old woman with dilated cardiomyopathy. The patient suffered from a cardiac electrical storm, with 98 episodes of ventricular tachycardia rapidly degenerating to ventricular fibrillation in hospital. The patient was converted with a total of 120 defibrillations. Recurrent ventricular tachycardia/fibrillation was initiate...

Background: Rhinoplasty is still one of the top five aesthetic surgeries performed and considered most challenging procedures in otorhinolaryngology surgery. Bleeding important factors affecting an operation's success. The controlled hypotension method reduces bleeding; therefore, it provides a satisfying bloodless surgical field during operation.
 Objective: To evaluate compare effectiven...

BACKGROUND The importance of decreasing bleeding in spine surgery is not only important to maintain the patient's hemodynamic balance but also allow a better view of the surgical field. OBJECTIVES The current study aimed to compare dexmedetomidine and Esmolol™ as agents to induce hypotension in lumbar spine surgeries. PATIENTS AND METHODS A total of 50 patients aged 20 to 65 years belonging...

The identification of radicals trapped in irradiated drugs can be very intricate. A multi-frequency electron paramagnetic resonance (EPR) study is proposed to resolve this problem. The Q-band (ca. 34 GHz) comparison with X-band (ca. 9 GHz) did not show significant differences for the four beta-blockers studied (atenolol, esmolol, nadolol and propranolol). The use of a higher frequency (285 GHz)...

OBJECTIVES Propofol causes considerable pain upon injection, although different methods and propofol formulations have been used to decrease this pain. We aimed to investigate the effect of i.v. esmolol pretreatment on propofol injection pain. METHODS Ninety ASA I-II patients undergoing elective surgery under general anesthesia were randomly assigned into three groups of thirty each. A 20 G c...

This study examined the effect of esmolol, an ultrashort-acting beta-receptor blocker, in 10 patients with severe left ventricular dysfunction. Simultaneous hemodynamic and radionuclide angiographic measurements were obtained at incremental doses of esmolol (2, 4, 8, 12 and 16 mg/min). At a dose of 4 mg/min, esmolol produced beats blockade: a decrease in heart rate from 91 +/- 4 to 83 +/- 4 bea...

Hao, Steven C., David J. Christini, Kenneth M. Stein, Peter N. Jordan, Sei Iwai, Orville Bramwell, Steven M. Markowitz, Suneet Mittal, and Bruce B. Lerman. Effect of -adrenergic blockade on dynamic electrical restitution in vivo. Am J Physiol Heart Circ Physiol 287: H390–H394, 2004. First published March 4, 2004; 10.1152/ajpheart.00749.2003.—The slope of the action potential duration (APD) rest...