OBJECTIVES To study the effect of escitalopram and fluoxetine on coagulation profile in patients with major depression. METHOD This was a prospective, open-label, single-centre study in 40 patients diagnosed with major depressive disorder. The patients were diagnosed using Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria. Twenty patients receiving escitalopram 10...

CONTEXT Insomnia and generalized anxiety disorder (GAD) are prevalent disorders that may coexist. OBJECTIVE To determine the efficacy of eszopiclone combined with escitalopram oxalate in treating insomnia comorbid with GAD. DESIGN Double-blind, randomized, placebo-controlled, parallel-group, add-on therapy 10-week study. SETTING Multicenter outpatient study from July 2005 to April 2006. ...

Case report. Ms A, a 40-year-old woman, had suffered from a first episode of moderate major depressive disorder (DSM-IV criteria). According to the clinical interview and to the Mini-International Neuropsychiatric Interview (MINI) questionnaire,1 she did not fulfill DSM-IV-TR criteria for any other Axis I or personality disorder. She was medically healthy and took no medications. The patient wa...

Two sensitive and validated methods were developed for determination of a racemic mixture citalopram and its enantiomer S-(+) escitalopram. The first method was based on direct measurement of the intrinsic fluorescence of escitalopram using sodium dodecyl sulfate as micelle enhancer. This was further applied to determine escitalopram in spiked human plasma, as well as in the presence of common ...

About 40% of patients treated with antidepressant do not show a response. However, the underlying mechanisms remain unclear and there is no objective test for the prediction of treatment response. The aim of this study was to investigate the proteomic differences between responder and non-responder in patients with major depressive disorder (MDD who were treated with escitalopram. Fasting blood...

OBJECTIVE To assess the antidepressant efficacy of S-adenosyl methionine (SAMe), a naturally occurring methyl donor, versus the selective serotonin reuptake inhibitor (SSRI) escitalopram and a placebo control; and to determine whether serum histamine or carnitine levels modified treatment response. METHODS We examined a subsample (n=144) from one site of a two-site study of adults with diagno...

BACKGROUND Depression is an increasingly important public health problem in China, but only a small minority of patients with this condition receive treatment. One of the reasons for low treatment rates is the relatively high cost of imported antidepressant medications. AIM Compare the efficacy and safety of the generic form of the selective serotonin re-uptake inhibitory (SSRI) antidepressan...

Escitalopram and sertraline are among the most widely used drugs in the treatment of depression in Norway. Both drugs show substantial pharmacokinetic variability. Previous studies have indicated that the drug metabolising enzyme cytochrome P450 2C19 (CYP2C19), which exhibits extensive variability in activity due to genetic polymorphism, is involved in the metabolism of escitalopram and sertral...

OBJECTIVES Elevated cortisol in stress and aging, such as has been seen in late-life anxiety disorders, is postulated to accelerate cognitive and physiological decline in this large and increasing population. Selective serotonin-reuptake inhibitors (SSRIs) and cognitive-behavioral therapy (CBT) are both effective treatments for generalized anxiety disorder (GAD) in older adults. On the other ha...