REV-ERB ALPHA has been shown to link metabolism with circadian rhythms. We aimed to identify new polymorphisms in the promoter of REV-ERB ALPHA and tested whether these polymorphisms could be associated with obesity in the Spanish population. Of the 1197 subjects included in our study, 779 were obese (BMI 34.38±3.1 kg/m2) and 418 lean (BMI 23.27±1.5 kg/m2). In the obese group, 469 of the 779 ha...

Phytoestrogens exert pleiotropic effects on cellular signaling and show some beneficial effects on estrogen-dependent diseases. However, due to activation/inhibition of the estrogen receptors ERa or ERb, these compounds may induce or inhibit estrogen action and, therefore, have the potential to disrupt estrogen signaling. We performed a comprehensive analysis and potency comparison of phytoestr...

ErbB2 is a prognostic factor and target of therapy for many carcinomas. In contrast with the other ErbB receptors, ErbB2 lacks a soluble direct ligand, but it is the preferred co-receptor for the ErbB family members, forming heterodimers with more potent and prolonged signalling activity than that of homodimers. We recently produced a new anti-ErbB2 antibody, Erb-hcAb, by fusion of Erbicin, a h...

In the present study, the efficacy of indole-3-carbinol (I3C), a key bioactive component of cruciferous vegetables, for prevention of cancer in offspring exposed in utero to the environmental carcinogen dibenzo[def,p]chrysene (DBC) was evaluated using an estrogen receptor b (ERb) knockout mouse model. I3Cwasprovided either through thematernal diet coincidentwith carcinogen exposure duringpregna...

BACKGROUND Elastic resistance bands (ERB) combined with proprioceptive neuromuscular facilitation (PNF) are often used in resistance muscle training programs, which have potential effects on peripheral muscle strength. However, the effects of the combination of ERB and PNF on respiratory muscle strength warrant further investigation. OBJECTIVES The assessment of the effects of PNF combined wi...

The coupling of specific antibodies to imaging agents often improves imaging specificity. However, free amine groups designed for the coupling can cause nonspecific binding of the imaging agents. We report here development of a nanocarrier, MnMEIO-silane-NH2-mPEG nanoparticles (NPs), consisting of a manganese-doped iron oxide nanoparticle core (MnMEIO), a copolymer shell of silane and amine-fun...

C-erbB2 is over-expressed or amplified in many carcinomas. We assessed the relationship between erb-B2 immunoreactivity, and its predictive role in progression-free survival and treatment outcome in patients with cervical carcinoma. Sections from 65 cervical carcinoma were immunostained with antibody to p185 erbB2. Immunoreactive ErbB2 was found in 25 patients (38%) [+ 15 pts. (23%); ++ 10 pts....

Benassayag, C., M. J. Leroy, V. Rigourd, B. Robert, J. C. Honoré, T. M. Mignot, M. C. Vacher-Lavenu, C. Chapron, and F. Ferré. Estrogen receptors (ERa/ERb) in normal and pathological growth of the human myometrium: pregnancy and leiomyoma. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E1112–E1118, 1999.—The distributions of the mRNAs for estrogen receptors (ERa and ERb) and their binding propert...

The erb nu -Ro u transformation, a computationally equivalent transformation proposed by erb nu and Ro u, converts a left-linear confluent normal conditional term rewriting system (CTRS) into an unconditional term rewriting system (TRS) which is computationally equivalent to the original CTRS. This paper aims at investigating su cient conditions for soundness of the erb nu -Ro u transformation ...