Background: Re-epithelialization has an important role in skin wound healing. Delays in re-epithelialization are more likely to create the chronic wound. Impaired wound healing leads to a large burden of morbidity and mortality. Current treatments based on the use of autografts, allografts and xenografts, suffer from limitations such as, quantity of donor skin available, donor-site infection, p...

Re-epithelialization is a complex process that involves migration and proliferation of keratinocytes, in addition to the production of cytokines and growth factors that affect other cells. The induction of transcription factors during these processes is crucial for successful wound healing. The transcription factor forkhead boxO-1 (FOXO1) has recently been found to be an important regulator of ...

Burns require a recovery process that multiplies complex biological mechanisms including anti-inflammatory, proliferation, and tissue remodeling. X.granatum J.Koenig (XG) is popular plant grows in the mangrove forest Bali. Traditionally, this used mainly for antiinflammation, dysentery, fever, skin emolliating, wound treatment, abdominal problems. Flavonoids, tannins saponins are active metabol...

Introduction. The search for methods to reduce the time of treatment burns and wounds donor sites currently remains relevant.Aim. Objective this retrospective study was evaluate effectiveness local II–IIIA degree site with dressings based on allogeneic type I collagen.Material methods. included 434 patients hospitalized in 2018–2021. Collagen were used 280 (234 46 wounds); 154 comparison group ...

An untapped therapeutic target for chronic wounds is the skin microbiota. Thus far, wound treatments have focused on eliminating pathogenic microbes, such as Staphylococcus aureus, that are known to delay healing. However, it not well understood how non-pathogenic bacterial colonization modulates healing, and if any colonizing bacteria confer a beneficial response. To initiate an investigation,...

Purpose To evaluate morselized amniotic membrane and umbilical cord (AMUC) eye drops in promoting corneal re-epithelialization. Methods Following a 2-mm diameter central epithelial wound in one eye of 48 normal C57BL/6 mouse corneas, 10 μL of saline with (n = 24) or without (n = 24) AMUC was applied three times a day for 6 days. The corneal epithelial defect was measured using 0.1% fluorescei...