In pre-surgical evaluation of pediatric epilepsy, the combined use of multiple imaging modalities for precise localization of the epileptogenic focus is a worthwhile endeavor. Advanced neuroimaging by high field Magnetic resonance imaging (MRI), diffusion tensor images, and MR spectroscopy have the potential to identify subtle lesions. (18)F-FDG positron emission tomography and single photon em...

Epileptic seizures of focal origin are classically considered to arise from a focal epileptogenic zone and then spread to other brain regions. This is a key concept for semiological electro-clinical correlations, localization of relevant structural lesions, and selection of patients for epilepsy surgery. Recent development in neuro-imaging and electro-physiology and combinations, thereof, have ...

Complete removal of epileptogenic cortex while preserving eloquent areas is crucial in patients undergoing epilepsy surgery. In this manuscript, the feasibility was explored of developing a new methodology based on dynamic intrinsic optical signal imaging (DIOSI) to intraoperatively detect and differentiate epileptogenic from eloquent cortices in pediatric patients with focal epilepsy. From 11 ...

Although patients suffering from medically intractable epilepsies originating from other than the temporal lobe are less numerbale than those with temporal lobe epilepsies (TLE), localization of the epileptogenic region in extratemporal epilepsies (ETE) is considered as much more demanding than in TLE [1, 2]. Even if seizure semiology may hint at the origin in specific parts of the brain [3-7],...

PURPOSE The aim of this study was to compare magnetoencephalography (MEG) and video-electroencephalography (VEEG) source localization in frontal lobe epilepsy (FLE) and determine if these methods can be complementary to each other in clinical practice. METHOD Thirty patients with pharmaco-resistant FLE who underwent epilepsy surgery were retrospectively enrolled. Video EEG was recorded using ...

Epilepsy is one of the most frequent chronic neurological disorders, affecting 1-2% of the population. Patients with complex partial drug resistant episodes may benefit from a surgical treatment consisting in the excision of the epileptogenic area. Localization of the epileptogenic area was classically performed with video-EEG and magnetic resonance (MR). Recently, functional neuroimaging studi...

The idea of attempting to eliminate epileptogenic foci by stereotactic means is not novel; it has been pursued since the 1960s. A range of ablation techniques has been used: from simple electrocoagulation to thermo-coupled electrocoagulation or radiosurgery, and, most recently, focused ultrasound. If the results of stereotactic treatment for epilepsy surgery have not been completely convincing ...