In this issue, we present the last of our series of reviews surveying epigenetics in hematology. We started with an overview of the foundations of epigenetics with respect to hematology and have explored the clinical relevance of epigenetics for each of the major classes of hematologic malignancies (Table 1). Here, we bring together observations from all of these reviews to highlight some of th...

Over the past 25 years, the broad field of epigenetics and, over the past decade in particular, the emerging field of neuroepigenetics have begun to have tremendous impact in the areas of learned behavior, neurotoxicology, CNS development, cognition, addiction, and psychopathology. However, epigenetics is such a new field that in most of these areas the impact is more in the category of fascina...

Downlo 13th American Association of Cancer Research (AACR) Special Conference on Cancer Epigenetics was n San Juan, Puerto Rico, on January 20–23, 2010. This event heralded insights arising from the large cing efforts within the NIH Epigenetics Roadmap Project and the Cancer Genome Atlas Project, as well ortant new discoveries in the basic biology of epigenetics and results of epigenetic drug c...

The rapid expansion of epigenetics research is fueled by the increasing understanding that epigenetic processes are critical to regulating cellular development and dysfunction of epigenetic programs is responsible for a diverse set of human pathologies, including cancer, autoimmune and neurodegenerative diseases. The expansive set of components contributing to epigenetic disease mechanisms and ...

Mitochondria, intracellular organelles with their own genome, have been shown capable of interacting with epigenetic mechanisms in at least four different ways. First, epigenetic mechanisms that regulate the expression of nuclear genome influence mitochondria by modulating the expression of nuclear-encoded mitochondrial genes. Second, a cell-specific mitochondrial DNA content (copy number) and ...

Autoimmune thyroid diseases (AITD) are a group of both B cell- and T cell-mediated organ-specific autoimmune diseases. Graves' disease and Hashimoto thyroiditis are the two main clinical presentations of AITD. Both genetic and environmental factors have important roles in the development of AITD. Epigenetics have been considered to exert key roles in integrating those genetic and environmental ...