Epigenetics refers to the DNA chemistry changes that result in modification of gene transcription and translation independently underlying coding sequence. Epigenetic modifications are reported involve various molecular mechanisms, including classical epigenetic affecting methylation histone small RNA-mediated processes, particularly microRNAs. reversible closely interconnected. They recognised...

in recent years of experience fetal hemoglobin (hbf) induction considers as novel therapeutic approach for β-thalassemia and sickle cell in therapeutic approaches. several pharmacologic agents such as hydroxyurea, azacytidine, butyrate deriviates and immunomodulator drugs like pomalidomide and lnalidomide could able to up-regulate hbf level with different molecular and epigenetic paterns (1-4)....

Mounting evidence linking epigenetic regulation to memory-related synaptic plasticity raises the possibility that altered chromatin modification dynamics might contribute to age-dependent cognitive decline. Here we show that the coordinated orchestration of both baseline and experience-dependent epigenetic regulation seen in the young adult hippocampus is lost in association with cognitive agin...

“Epigenetics” refers to changes in gene expression that occur through changes in DNA methylation, histone modification, small or micro-RNAs, or most inclusively, other mechanisms that alter how DNA sequences are translated into functional gene products. With the discovery that epigenetic modifications to gene expression can be inherited across cell lineages or even across organismal generations...

Epigenetic mechanisms play key roles in initiation and progression of prostate cancer by changing gene expression. The Prostate Epigenetic Database (PEpiD: http://wukong.tongji.edu.cn/pepid) archives the three extensively characterized epigenetic mechanisms DNA methylation, histone modification, and microRNA implicated in prostate cancer of human, mouse, and rat. PEpiD uses a distinct color sch...