Eukaryotic chromosomes occupy distinct territories within interphase nuclei. The arrangement of chromosome territories (CTs) is important for replication, transcription, repair and recombination processes. Our knowledge about interphase chromatin arrangement is mainly based on results from in situ labeling approaches. The phylogenetic affiliation of a species, cell cycle, differentiation status...

Engineering artificial tissue constructs requires the appropriate spatial arrangement of cells within scaffolds. The introduction of microengineering tools to the biological community has provided a valuable set of techniques to manipulate the cellular environment, and to examine how cell structure affects cellular function. Using micropatterning techniques, investigators have found that the ge...

We propose scalable architectures for the coherence-preserving qubits introduced by Bacon, Brown, and Whaley [Phys. Rev. Lett. 87, 247902 (2001)]. These architectures employ extra qubits providing additional degrees of freedom to the system. We show that these extra degrees of freedom can be used to counter errors in coupling strength within the coherence-preserving qubit and to combat interact...

Environmental law plays a key role in shaping policy for sustainability of social-ecological systems. In particular, the types of legal instruments, institutions, and the response of law to the inherent variability in social-ecological systems are critical. Sustainability likely must occur via the institutions we have in place, combined with alterations in policy and regulation within the conte...

Rapid advances in hand-held computing and communication capabilities, decreasing cost of mobile devices, and emergence of standards are fuelling the growth of mobile distributed work arrangement (DWA) in business operations. However, mobile DWA is more than a technological arrangement; it is an organizational innovation that could involve structural and administrative changes in the organizatio...

Allergic responses result from the activation of mast cells by the human high-affinity IgE receptor. IgE-mediated allergic reactions may develop to a variety of environmental compounds, but the initiation of a response requires the binding of IgE to its high-affinity receptor. We have solved the X-ray crystal structure of the antibody-binding domains of the human IgE receptor at 2.4 A resolutio...