Injured endothelium is an important target for drug and/or gene therapy because brain microvascular endothelial cells (BMECs) play critical roles in various pathophysiological conditions. RNA-mediated gene silencing presents a new therapeutic approach for treating such diseases, but major challenge is to ensure minimal toxicity and target delivery of siRNA to injured BMECs. Injured BMECs overex...

Purpose The purpose of this study is to examine the impact using proportional representation system on fragmentation party in Algerian political within period from 1997 2017, which Algeria has experienced five legislative elections regularly every years by testing a hypothesis about adopting basis closed list during foregoing obviously influenced exacerbation system’s fragmentation, compared ot...

Validated and easily applicable analytical tools are required to develop and implement regulatory frameworks and an appropriate risk assessment for engineered nanoparticles (ENPs). Concerning metal-based ENPs, two main aspects are the quantification of the absolute mass concentration and of the "dissolved" fraction in, e.g., (eco)toxicity and environmental studies. To provide information on pre...

BACKGROUND Relationships among portable scanning mobility particle sizer (P-SMPS), condensation particle counter (CPC), and surface area monitor (SAM), which are different metric measurement devices, were investigated, and two widely used research grade (RG)-SMPSs were compared to harmonize the measurement protocols. METHODS Pearson correlation analysis was performed to compare the relation b...

Los Espacios Naturales Protegidos (ENP) constituyen áreas a conservar dada su capacidad de generar bienes y servicios que benefician toda la población. La presión antrópica están sometidas estas origina necesidad implementar medidas para gestión conservación. El objetivo este trabajo es valorar económicamente las preferencias sociales sobre en el ENP del río Segura entorno paso por Cieza (Regió...

In this study, the effects, fate and transport of ENPs in wastewater treatment plants (WWTP) were investigated using three parallel pilot WWTPs operated under identical conditions. The WWTPs were spiked with (i) an ENP mixture consisting of silver oxide, titanium dioxide and zinc oxide, and (ii) bulk metal salts. The third plant served as control (unspiked). ENP effects were evaluated for (i) b...

The families of Edge Intersection Graphs of Paths in a tree (resp. in a grid) EPT (resp. EPG) are well studied graph classes. Recently we introduced the class of graphs of Edge-Intersecting and NonSplitting Paths in a Tree (ENPT) [2]. In this model, two vertices are adjacent if they represent two intersecting paths of a tree whose union is also a path. In this study we generalize this graph cla...

Canine distemper virus (CDV) and rabies virus (RABV) occur worldwide in wild carnivore and domestic dog populations and pose threats to wildlife conservation and public health. In Etosha National Park (ENP), Namibia, anthrax is endemic and generates carcasses frequently fed on by an unusually dense population of black-backed jackals (Canis mesomelas). Using serology, phylogenetic analyses (on s...

To address the ongoing debate over the impact of invasive species on native terrestrial wildlife, we conducted a large-scale experiment to test the hypothesis that invasive Burmese pythons (Python molurus bivittatus) were a cause of the precipitous decline of mammals in Everglades National Park (ENP). Evidence linking pythons to mammal declines has been indirect and there are reasons to questio...

Cysteinyl leukotrienes (CysLTs: leukotrienes C(4), D(4), and E(4)) have long been implicated in the pathogenesis of asthma and several allergic diseases. LTE(4) has been identified as a major metabolite of LTC(4), and urinary LTE(4) (U-LTE(4)) is considered as the most reliable analytic parameter for monitoring the endogenous synthesis of CysLTs. From recent studies on the U-LTE(4) associated w...