نتایج جستجو برای: enos protein

تعداد نتایج: 1236383  

Journal: :Hypertension 2010
Du-Hyong Cho Jungwon Seo Jung-Hyun Park Chulman Jo Yoon Jung Choi Jae-Won Soh Inho Jo

Nitric oxide (NO) production in endothelial cells (EC) is regulated by multisite phosphorylation of specific serine and threonine residues in endothelial NO synthase (eNOS). Among these, eNOS-Ser116 is phosphorylated in the basal state, and its phosphorylation contributes to basal NO production. Here, we investigated the mechanism by which eNOS-Ser116 is phosphorylated during the basal state us...

Journal: :Circulation research 2005
Jennifer K Bendall Nicholas J Alp Nicholas Warrick Shijie Cai David Adlam Kirk Rockett Mitsuhiro Yokoyama Seinosuke Kawashima Keith M Channon

Endothelial dysfunction in vascular disease states is associated with reduced NO bioactivity and increased superoxide (O2*-) production. Some data suggest that an important mechanism underlying endothelial dysfunction is endothelial NO synthase (eNOS) uncoupling, whereby eNOS generates O2*- rather than NO, possibly because of a mismatch between eNOS protein and its cofactor tetrahydrobiopterin ...

2010
Susan A. Austin Anantha V. Santhanam Zvonimir S. Katusic

of APP expression and processing in vivo, we used brain and cerebral microvessels from eNOS-deficient (eNOS / ) mice. Brain tissue from eNOS / mice had statistically higher APP and BACE1 protein levels, as well as increased BACE1 enzyme activity and A (A 1-42 wild-type control, 0.737pg/mg; eNOS / , 1.475 pg/mg; P<0.05), compared with wild-type controls (n 6 to 8 animals per background). Brain m...

Journal: :Cardiovascular research 2002
Shijie Cai Nicholas J Alp Denise McDonald Ian Smith Jonathan Kay Laura Canevari Simon Heales Keith M Channon

OBJECTIVES Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial nitric oxide synthase (eNOS) activity. BH4 levels are regulated by de novo biosynthesis; the rate-limiting enzyme is GTP cyclohydrolase I (GTPCH). BH4 activates and promotes homodimerisation of purified eNOS protein, but the intracellular mechanisms underlying BH4-mediated eNOS regulation in endothelial cells remain l...

Journal: :Reproduction 2006
Anna T Grazul-Bilska Chainarong Navanukraw Mary Lynn Johnson Daniel A Arnold Lawrence P Reynolds Dale A Redmer

This study was conducted to evaluate the expression of endothelial nitric oxide synthase (eNOS) in ovarian follicles and corpora lutea (CL) throughout the estrous cycle in sheep. Three experiments were conducted to (1) immunolocalize eNOS protein, (2) determine expression of mRNA for eNOS and its receptor guanylate cyclase 1 soluble beta3 (GUCY1B3), and (3) co-localize eNOS and vascular endothe...

Journal: :Circulation 2002
Senthil Kumar Venugopal Sridevi Devaraj Ivan Yuhanna Philip Shaul Ishwarlal Jialal

BACKGROUND C-reactive protein (CRP), the prototypic marker of inflammation, has been shown to be an independent predictor of cardiovascular events. Endothelial nitric oxide synthase (eNOS) deficiency is a pivotal event in atherogenesis. METHODS AND RESULTS We tested the effect of CRP on eNOS expression and bioactivity in cultured human aortic endothelial cells (HAECs). CRP decreased eNOS mRNA...

Journal: :American journal of physiology. Heart and circulatory physiology 1999
Trinidad de Frutos Lourdes Sánchez de Miguel Margarita García-Durán Fernando González-Fernández Juan A Rodríguez-Feo Mercedes Montón José Guerra Jerónimo Farré Santos Casado Antonio López-Farré

Despite the evidence that cytokines stimulate nitric oxide (NO) production by inducible nitric oxide synthase (iNOS), several reports recently demonstrated that the hypotensive response related to endothelial nitric oxide synthase (eNOS) activity could be inhibited by the same cytokines. The aim of the present work was to analyze whether NO generated by vascular smooth muscle cells (VSMC) could...

Journal: :The Journal of clinical investigation 1997
S M Black M J Johengen Z D Ma J Bristow S J Soifer

At birth, ventilation and oxygenation immediately decrease pulmonary vascular resistance (PVR) and increase pulmonary blood flow (PBF); more gradual changes occur over the next several hours. Nitric oxide, produced by endothelial nitric oxide synthase (eNOS), mediates these gradual changes. To determine how ventilation and oxygenation affect eNOS gene expression, 12 fetal lambs were ventilated ...

Journal: :Cardiovascular research 2009
Christoph A Schmitt Elke H Heiss Yasmin Aristei Theodor Severin Verena M Dirsch

AIM Pentoses are widely abundant in organic food. Thermal treatment of pentoses leads to the formation of norfuraneol (NF). The aim of this study was to show whether NF, which is taken up regularly, for example with cooked food, affects the human endothelial nitric oxide synthase (eNOS) system. METHODS AND RESULTS The study was performed using cultured human umbilical vein endothelial cells (...

Journal: :Stroke 2002
Roland Veltkamp Nishadi Rajapakse Greg Robins Michelle Puskar Katsuyoshi Shimizu David Busija

BACKGROUND AND PURPOSE Production of NO by endothelial NO synthase (eNOS) plays a protective role in cerebral ischemia. We studied the effects of transient focal ischemia on eNOS expression. METHODS Wistar rats (n=72) underwent reversible filament occlusion of the right middle cerebral artery for 75 minutes. After 6, 24, 72, or 168 hours of reperfusion, brains were removed and coronal section...

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