Background: Stem cell therapy for the treatment of vascular-related diseases through functional revascularization is one of the most important research areas in tissue engineering. The aim of this study was to investigate the in vitro differentiation of umbilical CL-MSC into endothelial lineage cells. Methods: In this study, isolated cells were characterized for expression of MSC-specific marke...

background: alpha-thalassemia syndrome includes a group of hereditary anemia in which expression of alpha globin chains is decreased or absent. impaired rbc in patients with thalassemia causes vessel involvement and endothelial cell vessel disturbance. vascular endothelial growth factor (vegf) is the most important regulator for endothelial cell proliferation. so, the aim of this study is to co...

Introduction: Human adipose-derived mesenchymal stem cells (hADSCs) are easily accessible in the body, and under appropriate conditions, they can be directed toward various phenotypes. Therefore, hADSCs have been considered as a potential cell source for tissue engineering applications. hADSCs are able to differentiate into endothelial cells which covers the interior surface of vessels, in vi...

Inducible nitric oxide synthase (iNOS) gene expresses a calcium calmudolin-independent enzyme which can catalyse NO production from L-arginine. The induction of iNOS activity has been demonstrated in a wide variety of cell types under stimulation with cytokines and lipopoly saccharide (LPS). Previous studies indicated that all nitric oxide synthases (NOS) activated in human umbilical vein endot...

Targeting platelet/endothelial cell adhesion molecule 1 enhances cisplatin sensitivity of human nasopharyngeal carcinoma cells exposed to ionizing radiation

We present a novel method for frequency-dependent microrheology on endothelial cell monolayer at high throughput and fluid flow.

cardiovascular disease remains the leading cause of morbidity and mortality in the united states and europe. in recent years, the understanding that regenerative processes exist at the level of the myocardium, has placed stem cell research at center stage in cardiology. a stem cell is a cell that has the ability to divide (self replicate) for indefinite periods often throughout the life of the ...

glomerular development of the kidney was studied in newborn rats by electron microscopy. four different stages of glomerular development were defined: vesicle fonnation, s-shaped body stage, capillary loop fonnation, and glomerular maturation. in the fust stage, the mesenchymal cells form a spheroid mass. this is followed by the s-shaped body stage in which clefts appear in the mass. afterwards...

The formation of de novo vascular structures is vital for melanoma growth and metastasis. Sox9 a transcription factor that highly upregulated in situations EndMT such as wound fibrosis or atherosclerosis well progenitors the endothelium (EVPs), playing crucial role stem cell self-renewal quiescence. In this study, we aimed to explore deletion on tumor vascularisation, metastasis, gene expressio...