Background Cysteine-rich protein 61 (CYR61/CCN1) is a growth factor-inducible gene, involved in the regulation of multiple cellular processes, such as cell adhesion, migration, survival, growth factor-induced mitogenesis, endothelial tubule formation, apoptosis and angiogenesis. In normal women endometrium, CYR61 expression is elevated during the proliferative phase of the menstrual cycle, and ...

BACKGROUND Apoptosis is a process that plays an important role during early stage of implantation. The aim of this study was to investigate the incidence of apoptosis in mice endometrium after ovarian stimulation at implantation period. METHODS NMRI female mice were divided into two groups: 1) control group, which were rendered pseudopregnant by vaginal stimulation and 2) experimental group, ...

OBJECTIVE To investigate the expression of vascular endothelial growth factor (VEGF) mRNA and thrombospondin-1 (TSP-1) mRNA in endometriosis. DESIGN Molecular studies in human tissue. SETTING Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, P. R. China. PATIENT(S) Patients undergoing...

BACKGROUND When ovarian carcinoma is diagnosed in stage I, up to 90% of patients can be cured with surgery and currently available chemotherapy. At present, less than 25% of cases are diagnosed at this stage. To increase the fraction of ovarian cancers detected at an early stage, screening strategies have been devised that utilize a rising serum CA125 level to trigger the performance of transva...

background: there are some controversial data on application of progesterone and progesterone plus estrogen at luteal phase. objective: to investigate the effects of different luteal support hormones on the alkaline phosphates (alp) activity in the endometrial epithelium and endometrial thickness during superovulation process for obtaining the optimized endometrial receptivity in animal model. ...

PURPOSE The presence of similar histologic subtypes of epithelial ovarian and endometrial cancers has long been noted, although the relevance of this finding to pathogenesis and clinical management is unclear. Despite similar clinical characteristics, histologic subtypes of cancers of the ovary and endometrium are treated according to organ of origin. This study compares the gene expression pro...

The aim of the present study was to evaluate the expression of the neo-angiogenic marker endoglin and its localization in tissues of normal and endometriotic patients as well as to compare it with one new angiogenic marker candidate - S100A13. Human recombinant S100A13 and endoglin 35mer synthetic peptide of the intracellular domain were used for the production of rabbit polyclonal antisera. Th...

The endometrium undergoes a dynamic proliferation of cells and vascular tissue under the influence ovarian steroid hormones. Implantation is an essential process in development pregnancy, where there close contact between embryo uterus, including supposition, adhesion, invasion. changes occur human endometrium, endometrial secretion changes, blood vessels, immune response, leading to uterine re...

Chemoresistance contributes to cancer relapse and increased mortality in a variety of cancer types, raising a pressing need to better understand the underlying mechanism. MUC1 is abnormally overexpressed in numerous carcinomas and associated with poor prognosis. However, the functional significance of MUC1 in chemoresistance has not been fully elucidated. Here, we showed that MUC1 expression wa...

Endocrinologic and metabolic abnormalities in polycystic ovary syndrome (PCOS) may have complex effects on the endometrium, contributing to the infertility endometrial disorders observed women with this  syndrome. The consequences of PCOS on homeostasis pathophysiology not been comprehensively understood. This review provides an overview molecular mechanisms endometrial  function with this path...