PURPOSE Endometriosis, a largely benign, chronic inflammatory disease, is an independent risk factor for endometrioid and clear cell epithelial ovarian tumors. We aimed to identify plasma miRNAs that can be used to differentiate patients with endometriosis and ovarian cancer from healthy individuals. EXPERIMENTAL DESIGN We conducted a two-stage exploratory study to investigate the use of plas...

Studies suggest that the presence of endometriosis may lead to impaired ovarian reserve, while results evaluating changes in antral follicle count (AFC) remain controversial. A systematic search returned 15 studies, which nine compared AFC between patients with and without endometriosis, five articles reported differences affected unaffected ovaries unilateral one both above two situations. Ove...

Study question Do genome-wide association study (GWAS) data for endometriosis provide insight into novel biological pathways associated with its pathogenesis? Summary answer GWAS analysis uncovered multiple pathways that are statistically enriched for genetic association signals, analysis of Stage A disease highlighted a novel variant in MAP3K4, while top pathways significantly associated wit...

objective: this study aimed to evaluate the levels of two oxidative stress (os) markers including lipid peroxide (lpo) and total antioxidant capacity (tac) in both serum and follicular fluid (ff) of women with endometriosis after puncture. materials and methods: in this cross-sectional study, a total number of sixty-three women younger than 40 years old with laparoscopy (gold standard for endom...

The objective of this prospective study was to assess the safety and short-term outcome of the Helica Thermal Coagulator in the laparoscopic treatment of early stage endometriosis. Two hundred and fifty consecutive women with chronic pelvic pain and stage I and II endometriosis (r-AFS classification) were treated laparoscopically with the Helica Thermal Coagulator. No bladder, ureteric or bowel...

PURPOSE Pelvic inflammatory disease is a rare complication of transvaginal oocyte retrieval. It results in failure of assisted reproductive procedure. PATIENTS During a 6-year period, 5958 transvaginal ultrasound-guided oocyte retrievals resulted in 10 cases of acute pelvic inflammatory disease (0.12%). RESULTS Eight of the 10 patients were diagnosed infertile because of endometriosis. Two ...

OBJECTIVE To investigate the influence of laparoscopic surgery on the natural conception rate in infertile women with endometriosis during the first year after the operation. METHODS We retrospectively studied 43 infertile women with surgically proven endometriosis. The natural conception rate was investigated for the 12 months after the laparoscopy. RESULTS The overall pregnancy rate was 4...

The present study aimed to investigate the presence of T regulatory cells (Tregs) in the peripheral blood (PB) and peritoneal fluid (PF) in females with endometriosis. The present study included 42 patients who underwent laparoscopy between 2010 and 2011. Flow cytometry was used to determine the percentage of Tregs in the PF and PB of the patients. No significant difference was observed in the ...

Erythropoietin (Epo) is an important regulator of erythropoiesis and stimulates the proliferation of early erythroid precursors as well as the differentiation of late erythroid precursors of the erythroid lineage. However, recent studies have indicated that Epo also has angiogenic properties and plays an important role in the oestrogen-dependent cyclical angiogenesis within the mouse uterus. It...

OBJECTIVE To investigate the clinical efficacy and safety of Helica Thermal Coagulator (TC) in the treatment of pelvic pain associated with minimal (stage I) and mild (stage II) endometriosis. DESIGN A clinical observational study. SETTING A referral center for laparoscopic treatment of endometriosis. PATIENT(S) Eighty-one women with pelvic pain symptoms associated with minimal and mild e...