نتایج جستجو برای: endocrine cell

تعداد نتایج: 1717915  

Journal: Iranian Journal of Blood and Cancer 2021
Diana Pereira, Harshaprasada Lashkari, Ramitha R Bhat, Stalin Ramprakash,

Regular packed cell transfusion in patients with thalassemia major leads to iron overload. Chelation therapy is one of the important aspects of thalassemia care as iron overload causes significant cardiac, hepatic, and endocrine dysfunction. We report a case of thalassemia major with severe iron overload causing cardiac and liver dysfunction who benefitted from triple drug chelation therapy. Tr...

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Journal: :Development 2007
Shelley B Nelson Ashleigh E Schaffer Maike Sander

Despite much progress in identifying transcriptional regulators that control the specification of the different pancreatic endocrine cell types, the spatiotemporal aspects of endocrine subtype specification have remained largely elusive. Here, we address the mechanism by which the transcription factors Nkx6.1 (Nkx6-1) and Nkx6.2 (Nkx6-2) orchestrate development of the endocrine alpha- and beta-...

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Journal: :Hormone research in paediatrics 2012
Chia-Lei Vivian Lin Patricia Myriam Vuguin

The development of the endocrine pancreas is regulated by several cell-matrix interactions that generate a diverse array of intracellular signals determining the progression of a multipotent progenitor to a mature endocrine cell. This process involves interactions between the epithelium, mesenchyma, and endothelial cells. Later in development, coordinated signaling contributes to the maintenanc...

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Journal: :Seminars in diagnostic pathology 2000
G Klöppel

Neoplasms of the pancreas usually show either ductal, acinar, or endocrine differentiation. Mixed exocrine-endocrine pancreatic neoplasms, in which the endocrine component is significant and comprises one-third to one-half of the tumor tissue, are rare. Truly mixed tumors have to be distinguished from exocrine neoplasms with scattered endocrine cells. In ductal adenocarcinomas, the scattered en...

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2012
Luis Arnes Jonathon T. Hill Stefanie Gross Mark A. Magnuson Lori Sussel

Pancreatic islet cells provide the major source of counteractive endocrine hormones required for maintaining glucose homeostasis; severe health problems result when these cell types are insufficiently active or reduced in number. Therefore, the process of islet endocrine cell lineage allocation is critical to ensure there is a correct balance of islet cell types. There are four endocrine cell t...

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Journal: :Cancer research 1992
K Yoshimoto H Iwahana A Fukuda T Sano S Saito M Itakura

To elucidate the molecular basis for endocrine tumorigenesis, p53 mutations in human endocrine tumors were analyzed by using polymerase chain reaction-single strand conformation polymorphism. Exons 5 through 10 of the p53 gene were studied in genomic DNAs from 134 primary endocrine tumors and 6 human endocrine cancer-derived cell lines. Mutations were detected and identified in 4 endocrine tumo...

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Journal: :The EMBO journal 2014
Cheng-Ran Xu Lin-Chen Li Greg Donahue Lei Ying Yu-Wei Zhang Paul Gadue Kenneth S Zaret

Endoderm cells undergo sequential fate choices to generate insulin-secreting beta cells. Ezh2 of the PRC2 complex, which generates H3K27me3, modulates the transition from endoderm to pancreas progenitors, but the role of Ezh2 and H3K27me3 in the next transition to endocrine progenitors is unknown. We isolated endoderm cells, pancreas progenitors, and endocrine progenitors from different staged ...

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2014
Kaoru Aida Sei Saitoh Yoriko Nishida Sadanori Yokota Shinichi Ohno Xiayang Mao Daiichiro Akiyama Shoichiro Tanaka Takuya Awata Akira Shimada Youichi Oikawa Hiroki Shimura Fumihiko Furuya Soichi Takizawa Masashi Ichijo Sayaka Ichijo Jun Itakura Hideki Fujii Akinori Hashiguchi Shin Takasawa Toyoshi Endo Tetsuro Kobayashi

BACKGROUND Pancreatic islet endocrine cell-supporting architectures, including islet encapsulating basement membranes (BMs), extracellular matrix (ECM), and possible cell clusters, are unclear. PROCEDURES The architectures around islet cell clusters, including BMs, ECM, and pancreatic acinar-like cell clusters, were studied in the non-diabetic state and in the inflamed milieu of fulminant typ...

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2016
Surjya Narayan Dash Elina Hakonen Jarkko Ustinov Timo Otonkoski Olov Andersson Sanna Lehtonen

Protection or restoration of pancreatic β-cell mass as a therapeutic treatment for type 1 diabetes requires understanding of the mechanisms that drive the specification and development of pancreatic endocrine cells. Septins are filamentous small GTPases that function in the regulation of cell division, cytoskeletal organization and membrane remodeling, and are involved in various tissue-specifi...

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Journal: :Development 2017
Yu-Ping Yang Mark A Magnuson Roland Stein Christopher V E Wright

The transcription factor Pdx1 is required for multiple aspects of pancreatic organogenesis. It remains unclear to what extent Pdx1 expression and function depend upon trans-activation through 5' conserved cis-regulatory regions and, in particular, whether the mammal-specific Area II (-2139 to -1958 bp) affects minor or major aspects of organogenesis. We show that Area II is a primary effector o...

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