The belief that pure single enantiomers would provide safer and more effective alternatives to racemates, has resulted in a greater stress on the evaluation and development of single isomers as drug products. Almost half of the drugs in use today are chiral. It is well established that the pharmacological activity is mostly restricted to one of the enantiomers and the individual enantiomers of ...

Enantiomers are chiral objects which di er by their orientation and are thus referred to as lefthanded and right-handed enantiomers. In applications they mostly occur as so-called racemic compounds consisting of approximately the same amount of leftand right-handed species which may have completely di erent properties. Hence, the separation of leftfrom right-handed enantiomers is an important i...

Modafinil is a synthetic molecule used for the treatment of narcolepsy. Narcolepsy is a neurological disorder, due to which people experience frequent excessive daytime sleepiness (EDS). Nevertheless, there are some concerns about modafnil quality control. The modafinil enantiomers are both biologically active. However, it has been reported that the pharmacological properties of the both enanti...

A hydrophilic chiral capillary monolithic column for enantiomer separation in CEC was prepared by coating cellulose tris(3,5-dimethylphenyl-carbamate) (CDMPC) on porous hydrophilic poly(acrylamide-co-N,N'-methylene-bisacrylamide) (poly(AA-co-MBA)) monolithic matrix with confine of a fused-silica capillary. The coating conditions were optimized to obtain a stable and reproducible chiral stationa...

Benazepril hydrochloride contains two stereogenic centers, but is currently available as single enantiomer (S,S configuration) for the treatment of hypertension. Its enantiomer (R,R configuration) and the diastereoisomeric pair (R,S and S,R) can be regarded as impurities. Stereochemical stability of S,S isomer of benazepril hydrochloride and its potential susceptibility to conversion in the.act...

Chiral induced spin selectivity is a phenomenon that has been attributed to chirality, spin-orbit interactions, and non-equilibrium conditions, while the role of electron exchange correlations have investigated only marginally until very recently. However, as recent experiments show chiral molecules acquire finite spin-polarization merely by being in contact with metallic surface, these results...